objective(s):   metal nanoparticles (nps) offer a wide variety of potential applications in pharmaceutical sciences due to the unique advances in nanotechnology research. in this work, bimetal ag-au alloy nps were prepared and their combinations with other antibiotics were tested against staphylococcus aureus.   materials and methods: firstly, ag-au alloy nps with au/ag molar ratio of 1:1 was f...

The wide use of titanium dioxide nanoparticles (TiO2 NPs) in industrial applications requires the investigation of their effects on human health. In this context, we investigated the effects of nanosized and bulk titania in two different crystalline forms (anatase and rutile) in vitro. By colony forming efficiency assay, a dose-dependent reduction of the clonogenic activity of Balb/3T3 mouse fi...

Surface-modified Ag/TiO2 photocatalysts with enhanced activity under visible light and biocidal properties have been produced through a two-stage method involving the functionalization of TiO2 nanoparticles(NPs) –SH or –NH terminated alkoxysilanes deposition AgNPs. The process increased yield Ag promoted more homogeneous distribution over surface. highest stability, homogeneity range absorption...

BACKGROUND AND AIM Sparse evidence suggests a possible link between exposure to airborne nanoparticles (NPs) and cardiovascular (CV) risk, perhaps through mechanisms involving oxidative stress and inflammation. We assessed the effects of TiO2 and Co3O4 NPs in human circulating angiogenic cells (CACs), which take part in vascular endothelium repair/replacement. METHODS CACs were isolated from ...

The present scanning tunneling microscopy study describes the high-temperature growth of TiO2 nanostripes with tunable width, orientation, and spacing, mediated by thermally stable micellar Pt and Au NPs deposited on TiO2(110). This phenomenon could not be explained by spillover effects but is based on the preferential stabilization of [11̅0] step edges on TiO2(110) by the metal NPs. Contrary to...

The ecotoxicity of nanoparticles (NPs) is a growing area of research with many challenges ahead. To be relevant, laboratory experiments must be performed with well-controlled and environmentally realistic (i.e., low) exposure doses. Moreover, when focusing on the intensively manufactured titanium dioxide (TiO2) NPs, sample preparations and chemical analysis are critical steps to meaningfully as...

Nanoparticles (NPs) of zinc oxide (ZnO) and titanium dioxide (TiO2) are receiving increasing attention due to their widespread applications. The aim of this study was to evaluate the toxic effect of ZnO and TiO2 NPs at different concentrations (50, 100, 250 and 500 ppm) and compare them with their respective salts using a battery of cytotoxicity, and genotoxicity parameters. To evaluate cytotox...

BACKGROUND Safety assessment of nanoparticles (NPs) requires techniques that are suitable to quantify tissue and cellular uptake of NPs. The most commonly applied techniques for this purpose are based on inductively coupled plasma mass spectrometry (ICP-MS). Here we apply and compare three different ICP-MS methods to investigate the cellular uptake of TiO2 (diameter 7 or 20 nm, respectively) an...

Ag core–TiO2 shell (Ag@TiO2) structured nanoparticles with Ag to TiO2 molar ratio of 1:1.7 were synthesized using one pot synthesis method and post calcination was carried out at 450 C for 3 h to convert it from amorphous to crystalline form. The Ag core and TiO2 shell formation was confirmed by TEM and AFM. The particle size analysis revealed the average size of Ag@TiO2 as approximately around...

The present study investigated the mechanism of N-acetyl-cysteine (NAC) inhibition on the cytotoxicity induced by titanium dioxide (TiO2) nanoparticles (NPs) using murine epidermal JB6 cells transfected with activator protein-1 (AP-1), JB6-AP-1 cells. Confocal microscopy was performed to localize TiO2 NPs in cultured cells. The level of reactive oxygen species (ROS) present in cells was evaluat...