Neuropeptide Y (NPY) receptors are present in cardiac membranes. However, its physiological roles in the heart are not clear. The aim of this study was to define the direct effects of pancreatic polypeptide (PP) on atrial dynamics and atrial natriuretic peptide (ANP) release in perfused beating atria. Pancreatic polypeptides, a NPY Y(4) receptor agonist, decreased atrial contractility but was n...

Different signals with key roles in energy homeostasis regulate the reproductive axis. These include neuropeptide Y and polypeptide YY(3-36), whose type Y(2) receptor is the most abundant of this family in the brain. We evaluated herein the putative roles of Y(2) receptors in the control of gonadotropin secretion by means of central administration of PYY(13-36) (agonist of Y(2) receptors) and B...

Peptide YY (PYY) is a 36 amino acid peptide hormone released from enteroendocrine cells. An N-terminally degraded metabolite, PYY3-36, has anorexigenic effects, which makes the PYY system a target for obesity treatment. However, little is known about the kinetics and degradation products of PYY. A related peptide, Neuropeptide Y (NPY), may be degraded from the C-terminus. We therefore investiga...

كچ ي هد فده و هقباس : هاگشناد تلاسر و مسج تملاس ءاقترا و نيصصختم تيبرت اه يم هعماج ناور دشاب . تسد يارب يباـي تلاسر نيا هب و دمآراك ،ملاس ،قيلا يناصصختم دنناوتب ات ،دنشاب ملاس دياب دوخ نانكراك ،لااو هعماج هب تبسن لوئسم دنيامن تيبرت . نيا زا تيولوا زا نانآ يناور تملاس تيعضو يسررب ور يم يتاقيقحت ياه دشاب . نيـيعت فده اب حرط نيا نا نانمس يكشزپ مولع هاگشناد نانكراك يناور تملاس تيعضو ديدرگ ماج ....

mIMCD-k2 cells are derived from the inner medullary collecting duct of a mouse and exhibit electrogenic sodium absorption and cAMP- and vasopressin (AVP)-stimulated electrogenic chloride secretion [N. L. Kizer, B. Lewis, and B. A. Stanton. Am. J. Physiol. 268 (Renal Fluid Electrolyte Physiol. 37): F347-F355, 1995; and N. L. Kizer, D. Vandorpe, B. Lewis, B. Bunting, J. Russell, and B. A. Stanton...

1 للملا نيب هبعش ،هيذغت مولع دشرا يسانشراك هتخومآ شناد ، يتشهب ديهش يكشزپ مولع هاگشناد 2 لوئسم هدنسيون : ميژر و ينيلاب هيذغت هورگ داتسا ينامرد ، هيذغت تاقيقحت وتيتسنا يا ،روشك يياذغ عيانص و ،يياذغ عيانص و هيذغت مولع هدكشناد هاگشناد يتشهب ديهش يكشزپ مولع . يكينورتكلا تسپ : [email protected] 3 يتشهب ديهش يكشزپ مولع هاگشناد ،يياذغ عيانص و هيذغت مولع هدكشناد ،هعماج هيذغت هورگ رايداتسا

Short-chain fatty acids (SCFAs) are recognized as the major anions of the large intestinal content in humans, but their effect on colonic motility is controversial. This study explores the colonic motor effect of SCFAs and their mechanisms in the rat. Colonic motility (electromyography) and transit time (plastic markers) were measured in conscious rats while SCFAs were infused into the colon, e...

Peptide YY3-36 (PYY) has emerged as an important signal in the gut-brain axis, with peripherally administered PYY affecting feeding and brain function. For these effects to be direct, PYY would have to cross the blood-brain barrier (BBB). Here, we determined the permeability of the BBB to PYY radioactively labeled with 131I (I-PYY). Multiple-time regression analysis showed the unidirectional in...

Aim of work: The role of pancreatic polypeptide family including Neuropeptide Y (NPY), and Peptide Tyrosine Tyrosine (PYY) in obesity development and its metabolic changes is controversial due to multiple receptor involvement. Therefore, this study was designed to investigate the effect of a potent Y2 receptor agonist; Peptide Tyrosine Tyrosine (PYY3-36) on high fat diet (HFD) induced obesity i...