PURPOSE Rosuvastatin is a poorly water soluble drug and the rate of its oral absorption is often controlled by the dissolution rate in the gastrointestinal tract. Hence it is necessary to increase the solubility of the Rosuvastatin. METHODS Several liquisolid tablets formulations containing various drug concentrations in liquid medication (ranging from 15% to 25% w/w) were prepared. The ratio...

Glucose monohydrate and sorbitol were evaluated as alternative carriers to á-lactose monohydrate in dry powder inhalations. Cromolyn sodium (CS) - carrier binary formulae were prepared and tested in vitro by aerosolization via a twin stage impinger using three types of inhaler devices; Spinhaler, Aerolizer and Handihaler. Glucose monohydrate and sorbitol-containing formulae that were inhaled vi...

*Centre of Expertise in Life Sciences, Zuyd University, Heerlen, the Netherlands, †Aerosil & Silanes, Degussa Corporation, Piscataway, NJ 08855, USA, ‡Toxicology and Environmental Research and Consulting, The Dow Chemical Company, Midland, MI 48674, USA, §Particle Engineering Research Center, University of Florida, Gainesville, FL 32611, USA, Institut für Toxikologie, Bayer HealthCare, Wupperta...

In this study, new composite materials of montmorillonite, biochar, or aerosil, containing metal–organic frameworks (MOF) were synthesized in situ. Overall, three different MOFs—CuBTC, UTSA-16, and UiO-66-BTEC—were used. Obtained adsorbents characterized using powder X-ray diffraction, thermogravimetric analysis, nitrogen adsorption porosimetry, scanning electron microscopy, energy-dispersive s...

Rivaroxaban (RN) is a recently developed potent oral anticoagulant. The aim of the present study envisages compatibility studies rivaroxaban with crospovidone, sodium startch glycolate, magnesium stearate, talc, microcrystalline cellulose, aerosil, HPMC K100 M, croscarmellose using Differential scanning calorimeter and FTIR spectrophotometer. DSC thermograms, physical mixture individual pharmac...

The aim of present study was to improve the solubility of pioglitazone HCl a practically insoluble antidiabetic drug by using liquisolid technique. The in vitro release pattern of liquisolid tablets and directly compressed tablets were studied using USP-II apparatus. Different Liquisolid tablets were prepared using a mathematical model to calculate the required quantities of powder and liquid i...

Purpose: To develop rosuvastatin calcium-loaded self-nanoemulsifying powder for improved oral delivery of the drug. Methods: Solubility study was carried out in different oils, surfactants and co-surfactants. Based on the solubility study, liquid formulations were prepared using LAS/Capryol 90: Maisine 35-1 as oil phase and Tween 20 with Lutrol E400 as surfactant mixture (Smix). The liquid form...

We studied the structure and the dynamics of a nanocolloidal silica gel dispersed in an organic solvent [octylcyanobiphenyl (8CB)] as a function of the silica density by x-ray intensity fluctuation spectroscopy (XIFS). The silica density of the dispersed aerosil gel samples ranged from 0.03 to 0.20 g cm-3 and the autocorrelation of the silica scattering was probed over the q range from 0.03 to ...