The purpose of this study is to develop a novel liquisolid technique to enhance the dissolution rate of poorly water soluble drug Carvedilol, a BCS class II drug, which is a β-blocker, by using different excipients. The main components of a liquisolid system are a non volatile solvent, carrier and coating materials and a disintegrant. Liquisolid system refers to the formulations that are formed...

The purpose of this study was to prepare a dutasteride-loaded solid-supersaturatable self-microemulsifying drug delivery system (SMEDDS) using hydrophilic additives with high oral bioavailability, and to determine if there was a correlation between the in vitro dissolution data and the in vivo pharmacokinetic parameters of this delivery system in rats. A dutasteride-loaded solid-supersaturatabl...

High-resolution calorimetric studies have been made of the liquid crystal phase transitions for several dispersions of 70-Å-diam silica spheres ~aerosil! in octylcyanobiphenyl ~8CB! as a function of silica density rS . The excess specific heat peaks associated with the nematic-isotropic (N-I) and the nematic–smectic-A (N-SmA) transitions both exhibit shifts to lower temperatures, decreases in t...

Preformulation is an important step in the rational formulation of an active pharmaceutical ingredient (API). Micromeritics properties: bulk density (BD) and tapped density (TD), compressibility index (Carr's index), Hauser's ratio (H), and sieve analysis were performed in order to determine the best excipients to be used in the formulation development of omeprazole magnesium enteric coated tab...

Frequency dispersion studies on proton spin-lattice relaxation rates of a liquid crysal (4’-octyloxy-4-cyanobiphenyl) embedded in Aerosil matrix show significant increase at low frequencies (sub-MHz regime) relative to the bulk sample, and are interpreted as primarily due to slow reorientations near the surface ordered layers mediated by translation displacements. The computed exponent in the p...

The effects of dispersed aerosil nanoparticles on two of the phase transitions of the thermotropic liquid-crystal material 4-n-pentylphenylthiol-4(')-n-octyloxybenzoate (8;S5) have been studied using high-resolution x-ray diffraction techniques. The aerosils hydrogen bond together to form a gel which imposes a weak quenched disorder on the liquid crystal. The smectic-A fluctuations are well cha...

The viscous flow behavior of a 12.5 vol% hydrophobic fumed silica (Aerosil® R816) suspension in polypropylene glycol low molecular weight (PPG400) was studied stress-controlled rheometer. steady curve showed shear thickening between two thinning regions. Time-dependent viscosity response provoked by step changes stresses corresponding to the shear-thickening region apparently agrees with thixot...