Background: Glycation of proteins is a non-enzymatic spontaneous process that occurs in diabetes mellitus and aging, altering the structure and function of proteins. IgG undergoes glycation leading to changes in its reactivity to antigen and fixation of complement.   Objective: This study aimed at revealing the effect of glycation on the interaction of IgG with anti-IgG using electroimmunoassay...

non-enzymatic glycosylation of proteins is one of the key mechanisms in the pathogenesis of diabetic complications. glycation of igg is of special interest due to its possible influence on the functionality of immunoglobulins and overall immuno-competence. the aim of this study was to clarify more details of in vitro glycation of igg and to study the effect of this modification on its interatio...

oxidative stress and protein glycation play pivotal roles in the pathophysiology of diabetes mellitus and its vascular complications. the present study aimed to investigate the anti-glycation properties of essential oils obtained from different parts of juniperus communis subsp. hemisphaerica . the branchlets of male tree (bmt) and branchlets of female (bft) tree, and fruits of j. communis subs...

We isolated and identified the glyceraldehyde-derived advanced glycation product (AGE) formed from glyceraldehyde and N(alpha)-acetylarginine. A major product was identified as N(alpha)-acetyl-N(delta)-(5-methyl-imidazolin-4-one-2-yl)-ornithine. The compound has been reported as methylglyoxal-derived AGE, MG-H1. This study suggests that MG-H1 is formed through both glyceraldehyde-related and me...

This paper describes a system for accomplishing product engineering, called a Product Design Generator (PDG). Four rules for successful product engineering processes are posited by analogy with the Toyota Production System. An overview of the PDG method is presented as well as an industrial case study, which demonstrates the impact and potential for successful implementation of the method. This...

OBJECTIVE Advanced glycation end-products are considered to be markers of oxidative stress and to be involved in the atherosclerotic process. We investigated skin autofluorescence, which reflected advanced glycation end-product accumulation, in recently preeclamptic women and its relationship with intima-media thickness, which is a marker of atherosclerosis. STUDY DESIGN Skin autofluorescence...

We thank Conway et al. (1) for the discussion of their findings regarding skin intrinsic fluorescence in the Pittsburgh Epidemiology of Diabetes Complications (EDC) study cohort. Their results—that skin intrinsic fluorescence values are higher in individuals with no diabetic retinopathy (DR) as compared with more advanced DR—are consistent with our findings in the Medalist cohort in which incre...