OBJECTIVES To identify a novel, generalizable diagnostic for acute respiratory distress syndrome using whole-blood gene expression arrays from multiple acute respiratory distress syndrome cohorts of varying etiologies. DATA SOURCES We performed a systematic search for human whole-blood gene expression arrays of acute respiratory distress syndrome in National Institutes of Health Gene Expressi...

W e have reported previously on abnormalities of human surf actant in a lung from a patient with the adult respiratory distress syndrome (ARDS) following trauma and shock.’ The lung with ARDS was compared to three normal lungs obtained from transplant donors. An abnormal static pressure-volume curve indicated reduced compliance and abnormally high surfactant film compressibility was found, but ...

The adult respiratory distress syndrome (ARDS) is characterised by hypoxaemia, bilateral pulmonary infiltrates due to increased permeability, pulmonary oedema and, in most but not all instances, reduced lung compliance. The yearly incidence of ARDS is approximately six per 100 000. ARDS may occur in response to various direct or indirect insults to the lung. Gastric aspiration, bacterial or pne...

Most survivors of ARDS have persistent mild reductions of TLCO even as long as a year after their episode. The lung volumes and flows return to normal in most instances, although a subset of patients will have persistent impairment. Both obstructive and restrictive deficits may be seen. This group may be predicted by the degree of acute lung injury assessed by the level of FIO2, PEEP, and gas e...

The adult respiratory distress syndrome (ARDS) is characterised by hypoxaemia, bilateral pulmonary infiltrates due to increased permeability, pulmonary oedema and, in most but not all instances, reduced lung compliance. The yearly incidence of ARDS is approximately six per 100 000. ARDS may occur in response to various direct or indirect insults to the lung. Gastric aspiration, bacterial or pne...

ARDS yearly afflicts more than 150,000 people, many of whom are young and otherwise healthy and yet the mortality rate remains in excess of 60% to 70%. This high mortality has not yielded to the significant gains made in intensive care patient management and rapid advances in technology. Acute lung injury research in the past 15 to 20 years has greatly enhanced our understanding of the pathophy...