Characterization of adrenergic receptors in membranes from the rat seminal vesicle was studied by radioligand binding assay. Seminal vesicle membranes contained saturable and high affinity binding sites for the beta-adrenergic receptor antagonist 3H-dihydroalprenolol (3H-DHA) and for the alpha-adrenergic antagonist 3H-prazosin. The observed order of potency for adrenergic agonists in competing ...

OBJECTIVE We examined the relationship between beta-adrenergic receptor responsiveness and hostility and social support in African American and white men and women. METHODS The participants were 149 men and women, aged 25 to 45 years with SBP < 160 and DBP < 105. Hostility and social support were assessed with standardized self-report measures. An isoproterenol challenge was used to evaluate ...

Introduction: Feverfew (Tanacetum parthenium) (T.p.) is widely used in folk medicine to treat many diseases. We reported the analgesic effect of T.p. flower and leaf previously. Present study is designed to find the mechanism underlying the anti-nociceptive effect of the aqueous extract of T.p. flower. Method: Based on our previous study, the dose 50 mg/kg i.p. of the T.p. aqueous extract had...

SUMMARY  The foliowing cardiac effects may be at­tributed to thyroxin:  1-Thyroxin augments all anaerobic pro­cesses in the body includ::ng the heart, and decreases the glycogen content of the heart ( 1, 2, 5, 27). The resistance of the heart to anoxia is increased in hyperthyroidism ( 25). 2- Thyroxin influences the cardiac weight and prevents cardiac atrophy (3, 8, 10, 11, 19, 20, 21, 30...

BNST: bed nucleus of the stria terminalis; CRF: corticotropin releasing factor; VTA: ventral tegmental area Recommended journal section: Neuropharmacology This article has not been copyedited and formatted. The final version may differ from this version. ABSTRACT Stress can trigger relapse of drug use in recovering cocaine addicts and reinstatement in rodent models through mechanisms that appea...

[3H]Dihydroergocryptine, a potent a-adrenergic antagonist, was used to label smooth muscle membrane binding sites which have the characteristics expected of a-adrenergic receptors. Binding of [3H]dihydroergocryptine to rabbit uterine membranes was rapid and reversible with rate constants of 1.26 x lo1 M-I min ~’ and 0.034 min’ for the forward and reverse reactions, respectively. [3H]Dihydroergo...

[3H]Dihydroergocryptine, a potent alpha-adrenergic antagonist, was used to label smooth muscle membrane binding sites which have the characteristics expected of alpha-adrenergic receptors. Binding of [3H]dihydroergocryptine to rabbit uterine membranes was rapid and reversible with rate constants of 1.26 X 10(7) M-1 min-1 and 0.034 min-1 for the forward and reverse reactions, respectively. [3H]D...

NMR methods provide information about conformational dynamics of GPCRs over a wide range frequencies in aqueous media at near-physiological temperature, with minimal modification the wild-type GPCR covalent structures. Here we review our solution studies functionrelated GPCRs, including β2 adrenergic receptor, μ opioid and adenosine A2A receptor.