The melanocortin-2-receptor (MC2R)/MC2R accessory protein (MRAP) complex is critical to the production of glucocorticoids from the adrenal cortex. Inactivating mutations in either MC2R or MRAP result in the clinical condition familial glucocorticoid deficiency. The localisation of MC2R together with MRAP within the adrenal gland has not previously been reported. Furthermore, MRAP2, a paralogue ...

Twenty-three unilaterally adrenalectomized guinea pigs were injected with autologous and homologous adrenal tissue homogenates respectively, in Freund's adjuvant. Widespread adrenal lesions were found in 10 of 12 animals receiving auto-antigen and to a lesser extent in 6 of 11 animals injected with homologous pooled antigen. Widespread systemic lesions were present in both these and in control ...

For more than a decade the secretions of the adrenal cortex have been associated with the metabolism of protein. The work of Long and his collaborators clearly demonstrated that the administration of potent adrenal cortical extracts to experimental animals resulted in increased gluconeogenesis, associated with accentuated nitrogen excretion (l-3). This effect of the adrenal cortex on the catabo...

The response of the adrenal cortex to exogenous ACTH has been recognized as one of the more specific and quantitative tests of adrenal function (1). Changes in the 24-hour excretion values of urinary 17-ketosteroids and 17-hydroxycorticosteroids during ACTH administration have proved to be valuable indices of adrenocortical capacity (2, 3). With the development of technics for the chemical esti...

An antibody preparation to purified, homogeneous TPNHcytochrome c reductase from pig liver microsomes was shown to inhibit concomitantly TPNH-cytochrome c reductase (NADPH-cytochrome c oxidoreductase, EC 1.6.2.3) and ethyhnorphine N-demethylase activities in pig liver microsomes. The antibody also inhibited TPNH-cytochrome c reductase and TPNH-cytochrome P-450 reductase activities in rat and pi...

Objective(s): Diabetes mellitus (DM) is a widespread metabolic disorder worldwide. Clinical physicians have found diabetic patients have mild to middle cognitive dysfunction and an alteration of brain monoaminergic function. This study explored the change in various patterns of behavioral models and brain monoamine function under streptozotocin (STZ)-induced type 1 diabetes.Materials and Method...