The aim of this study was to determine the strong candidate genes increasing susceptibility to obesity among previously reported obesity-related genes in Korean subjects and evaluate gene-environmental interactions in susceptibility to obesity. The study population comprised of 163 adolescents (95 boys and 68 girls) and their parents (97 men and 96 women).We used multivariable-adjusted logisti...

AIMS Carvedilol is an effective treatment in hypertension and chronic heart failure. The medical impact of polymorphisms in CYP2D6 and in the β-adrenergic receptors ADRB1 and ADRB2 on the pharmacokinetics and pharmacodynamics of carvedilol is controversial. METHODS After carvedilol 25 mg was administered to 110 volunteers, concentrations were enantioselectively quantified and effects on resti...

Objective A matched case-control study was conducted in a Spanish children and adolescent population (5-18 years old), to assess the interaction between the Gln27Glu polymorphism of the ADRB2 and television (TV) watching on obesity risk. 25

The management of premature birth still remains unsatisfactory. Since the relative lack of efficiency and/or safety of current tocolytic agents have been highlighted, it is necessary to develop new uterorelaxant drugs deprived of important maternal and foetal side effects. Our work reported in this review focuses on a potential new target for tocolytic drugs, the beta3-adrenoceptor (ADRB3). Thi...

EXPLORATION of the 2-adrenergic receptor (ADRB2) has been the holy grail of asthma pharmacogenetics research since the gene was cloned two decades ago. The evolution in our understanding of genetic variants in the ADRB2 reflects both the progress and the limitations in exploring the contributions of an important candidate gene within a complex phenotype such as asthma. As the G protein-coupled ...

Introduction The gene encoding β2-adrenergic receptor (ADRB2) is a candidate for chronic obstructive pulmonary disease (COPD), yet the results are not often reproducible. We aimed to assess association of ADRB2 genetic polymorphisms (rs1042713, rs1042714, and rs1800888) with COPD risk COPD-related phenotypes via meta-analysis. Material methods Literature search, quality evaluation, data extract...

Recently, the biased β2-adrenoceptor/β-arrestin pathway was shown to play a pivotal role in crossing of the blood brain barrier by Neisseria meningitidis. We hypothesized that genetic variation in the β2-adrenoceptor gene (ADRB2) may influence susceptibility to bacterial meningitis. In a prospective genetic association study we genotyped 542 patients with CSF culture proven community acquired b...

Cerebral non-oxidative carbohydrate consumption may be driven by a β2-adrenergic mechanism. This study tested whether the 46G > A (G16R) single nucleotide polymorphism of the β2-adrenergic receptor gene (ADRB2) influences the metabolic and cerebrovascular responses to administration of adrenaline. Forty healthy Caucasian men were included from a group of genotyped individuals. Cardio- and cereb...