Editorial BIOINFORMATICS NEEDS TO ADOPT STATISTICAL THINKING Until a couple of years ago a typical question from my colleagues on the biological workbench would be phrased something like: " I have this sequence here and cannot find out anything about it. Can you help? ". From today's standpoint two things are remarkable about this question. First, it deals with only one sequence. Today, the que...

Epstein-Barr Virus (EBV) can establish latent infections with distinct gene expression patterns referred to as latency types. These different latency types are epigenetically stable and correspond to different promoter utilization. Here we explore the three-dimensional conformations of the EBV genome in different latency types. We employed Chromosome Conformation Capture (3C) assay to investiga...

This work studies how the notion of accountability can play a key role in the design and realization of distributed systems that are open and that involve autonomous agents that should harmonize their own goals with the organizational goals. The socio–technical systems that support the work inside human companies and organizations are examples of such systems. The approach that is proposed in o...