Reproductive functions decline with the onset of diabetes in female mice. Diabetic mice have smaller uteri with an underdeveloped endometrium, suggesting diminished estrogen-induced growth. We aimed to clarify the changes in the estrous cycle and in insulin-like growth factor 1 (IGF1) expression in the uteri of streptozotocin (STZ)-treated diabetic mice, because IGF1 is one of the main growth f...

Latar belakang: Angka Kematian Ibu (AKI) merupakan salah satu indikator penting dalam menilai derajat kesehatan. Status kesehatan secara umum, satunya indikatornya perdarahan postpartum. Berdasarkan survei penduduk antar sensus pada 2015, angka kematian ibu di Indonesia sebesar 305 per 100.000 kelahiran hidup. Pada hal harapkan AKI tahun 2015 turun menjadi 102/ (WHO, 2015). Penyebab utama sesua...

IGF-I is a critical regulator of uterine growth, and locally produced uterine IGF-I could mediate the effects of 17beta-E2 on growth and cellular proliferation. We used IGF-I knockout (KO) mice and tissue grafting to determine the roles of local and systemic IGF-I in uterine growth and E2 responsiveness. Uteri from adult KO mice and neonatal and adult wild-type (WT) mice were grown under the re...

BACKGROUND Accumulating evidence suggests that Fructus Ligustri Lucidi (FLL) plays a beneficial role in preventing the development of osteoporosis. However, the effects of FLL on estrogen receptor (ER) α and ERβ expressions remain unknown. Therefore, in the current study we attempted to probe into the effects of FLL on ERα and ERβ expressions in femurs, tibias and uteri of ovariectomized (OVX) ...

Adnexal torsion is rare but an urgent surgical condition that usually occurs in women of reproductive age. The recommended treatment is immediate laparotomy. We present an example of torsion of normal adnexa during early pregnancy. Laparoscopy was used to establish the diagnosis and for the definitive treatment and pregnancy continued without any further problems. We consider that laparoscopic ...

Sarcoma of the corpus uteri should be considered as a differential diagnosis in postmenopausal women presenting with severe abdominal pain, thought to be due to degenerative changes of leiomyoma uteri. We present a rare case of leiomyosarcoma in a postmenopausal White woman. Diagnosis was missed preoperatively for degenerating uterine fibroid.

Background. Ectopic pregnancy is one of the leading causes of significant maternal morbidity and mortality. Abdominal surgeries increase the risk of postoperative adhesions. We here present a case of omental ectopic pregnancy in a patient with a prior history of cesarean section. Case. A 20-year-old female presented with a two-day history of crampy lower abdominal pain. Patient was hemodynamica...

In former writings on this subject, especially in the "Edinburgh Medical Journal" for January 1872, I have insisted on the purely mechanical nature of this disease; that it is like a dislocation or a hernia; that, if hypertrophy favours its production, it is by the increase of weight it implies; that, if relaxation or laceration of tissues favour its production, it is by removal or diminution o...