INTRODUCTION: Adipose tissue serves as a viable source of stem cells due to its relative ease of collection and availability in patients. We have previously isolated adipose derived stem cells (ADSCs) from subcutaneous fat from C57BL mice and demonstrate their regeneration potential for musculoskeletal tissue (1). ADSCs hold potential in cell therapy for a variety of musculoskeletal injuries an...

INTRODUCTION Recent evidence suggests that the implantation of bone marrow-derived mesenchymal stem cells improves peripheral nerve regeneration. In this study we aimed to investigate whether adipose-derived stem cells (ADSCs) can be used for peripheral nerve repair. MATERIAL AND METHODS In a rat model, nerve regeneration was evaluated across a 15 mm lesion in the sciatic nerve by using an ac...

Articular cartilage injury and defect caused by trauma and chronic osteoarthritis vascularity are very common, while the repair of injured cartilage remains a great challenge due to its limited healing capacity. Stem cell-based tissue engineering provides a promising treatment option for injured articular cartilage because of the cells potential for multiple differentiations. However, its appli...

Abstract Adipose-derived stem cells (AdSCs), a type of mesenchymal cell, are expected to be applicable regenerative medicine and cellular delivery systems. The maintenance cell multipotency control the differentiation direction important for these applications. However, is widely believed depend on physical properties their scaffold. In this study, we explored whether AdSCs, that is, ability di...

introduction: human adipose-derived mesenchymal stem cells (hadscs) are easily accessible in the body, and under appropriate conditions, they can be directed toward various phenotypes. therefore, hadscs have been considered as a potential cell source for tissue engineering applications. hadscs are able to differentiate into endothelial cells which covers the interior surface of vessels, in vivo...

Abstract Changes that occur to the stem cell microenvironment with disease are a major consideration may affect behavior and potential therapeutic efficacy of mesenchymal cells (MSCs). The purpose this study is evaluate effects adipose-derived MSCs (ADSCs) from obese mice hyperglycemia on body weight glucose homeostasis. After 10 weeks high-fat diet, were injected phosphate-buffered saline (PBS...

traffic accident has increased in the last decade. one of the most important outcomes of accident is spinal cord injury (sci). so, cell therapy is obtained a greater attention in most fields of medicine because of its potential for incurable diseases through replacing of dead cells. the current study aims to describe the important of locomotor functional and structural connection of the spinal ...

The cellular origin of soft tissue sarcomas (STSs) is not fully understood. The cancer stem cell hypothesis presumes that tumors originate from the malignant transformation of stem cells. As a type of multipotent stem cell, adipose tissue-derived stromal/stem cells (ADSCs), which possess an unexpected degree of plasticity and often reside in other tissues, may represent a potential source of so...

Medialization thyroplasty or injection laryngoplasty for unilateral vocal fold paralysis cannot restore mobility of the vocal fold. Recent studies have shown that transplantation of mesenchymal stem cells is effective in the repair of nerve injuries. This study investigated whether adipose-derived stem cell transplantation could repair recurrent laryngeal nerve injury. Rat models of recurrent l...