AIMS Stimulation of β-adrenergic receptors (β-AR) increases cAMP production and contributes to the pathogenesis of cardiac hypertrophy and failure through poorly understood mechanisms. We previously demonstrated that Exchange protein directly activated by cAMP 1 (Epac1)-induced hypertrophy in primary cardiomyocytes. Among the mechanisms triggered by cardiac stress, autophagy has been highlighte...

in this paper, the enhancement of vehicle stability and handling is investigated by control of the active geometry suspension system (ags). this system could be changed through control of suspension mounting point’s position in the perpendicular direction to wishbone therefore the dynamic is alternative and characteristics need to change. for this purpose, suitable controller needs to change mo...

background: allergic diseases have increased during the past decade worldwide. th2 type lymphocyte response is known to play an important role in the process of allergic inflammation. il-4, a mediator of type ii cytokine response increases ige synthesis and interferon gamma, a cytokine of type i response interferes with il-4 and inhibits ige production. selenium is an essential component of glu...

In this article we analyze several vibration time series measured on a real fan test rig before and after it is hit by a flying object. We show first evidence that a windowed autoregressive model may be used to detect the shock after it occurred. We compare these results with a second time series that measures the rotation period of the fan. Lastly we repeat this experiment using adaptive autor...

In this paper, we describe a new adaptive system for the enhancement of autoregressive (AR) signals which are disturbed by additive broadband noise. The system is comprised of an adaptive Kalman filter operating as a fixed-lag smoother and a subsystem for AR parameter estimation. As opposed to the conventional approach of employing an extended Kalman filter, we estimate the Kalman filter parame...

Primarily the structured auto-regressive (AR) model was introduced as a mean to estimate the parameters of non-stationary signals in additive noise. However, it is straightforward to use the structured AR model as a model-based time-frequency distribution (TFD). It is shown that the structured AR TFD can be interpreted as a member of Cohen's class with a non-stationary adaptive kernel. The inte...

In this article, we consider the problem of adaptive detection for a multichannel signal in the presence of spatially and temporally colored compound-Gaussian disturbance. By modeling the disturbance as a multichannel autoregressive (AR) process, we first derive a parametric generalized likelihood ratio test against compoundGaussian disturbance (CG-PGLRT) assuming that the true multichannel AR ...

Nonlinear static procedure (NSP) is a common technique to predict seismic demands on various building structures by subjecting a monotonically increasing horizontal loading (pushover) to the structure. Therefore, the pushover analysis is an important part of each NSP. Accordingly, the current paper aims at investigating the efficiencyof various algorithms of lateral load patterns applied to the...

OBJECTIVE To investigate the use of intravascular ultrasound (IVUS) in detecting the presence of arterial remodelling in patients with unstable angina. DESIGN Prospective case study. PATIENTS 60 of 95 consecutively admitted patients with unstable angina (41 male, 19 female), mean (SD) age 61.2 (8.1) years. INTERVENTIONS Qualitative and quantitative coronary angiography and IVUS. MAIN OU...