The substrate specificity of 1-acylglycerol 3-phosphate acyltransferase from rat liver microsomes for both acylcoenzyme A and I-acylglycerol 3-phosphate has been determined at levels below the critical micelle concentrations of the substrates. The fatty acid of the acylglycerol 3-phosphate is not important, but for the acyl-CoAs the specificity is oleyl > palmitoleyl N linoleyl N palmityl > myr...

2,3-Dihydroxybiphenyl 1,2-dioxygenase (EC ), the extradiol dioxygenase of the biphenyl biodegradation pathway, is subject to inactivation during the steady-state cleavage of catechols. Detailed analysis revealed that this inactivation was similar to the O(2)-dependent inactivation of the enzyme in the absence of catecholic substrate, resulting in oxidation of the active site Fe(II) to Fe(III). ...

The mechanism-based inactivations of a number of serine proteases, including human leukocyte (HL) elastase, cathepsin G, rat mast cell proteases I and II, several human and bovine blood coagulation proteases, and human factor D by substituted isocoumarins and phthalides which contain masked acyl chloride or anhydride moieties, are reported. 3,4-Dichloroisocoumarin, the most potent inhibitor inv...

2,3-Dihydroxybiphenyl 1,2-dioxygenase (EC 1.13.11.39), the extradiol dioxygenase of the biphenyl biodegradation pathway, is subject to inactivation during the steadystate cleavage of catechols. Detailed analysis revealed that this inactivation was similar to the O2-dependent inactivation of the enzyme in the absence of catecholic substrate, resulting in oxidation of the active site Fe(II) to Fe...

The β-blocker (S)-esmolol, has been synthesized in 97% enantiomeric excess and 26% total yield a four-step synthesis, with transesterification step of the racemic chlorohydrin methyl 3-(4-(3-chloro-2-hydroxypropoxy)phenyl)propanoate, catalysed by lipase B from Candida antarctica Syncozymes, Shanghai, China. (S)-penbutolol, 99% 22% yield. 1-chloro-3-(2-cyclopentylphenoxy)propan-2-ol was catalyze...

bacteria use a chemical language to communicate with each other which enables them to synchronize gene expression as a result of cell density. this special language which is called quorum sensing (qs) is based on producing and sensing the small signals and eventually leads them to perceive when a minimum population unit is reached. on the contrary, quorum sensing blockade (quorum quenching) has...

background: n-acyl homoserine lactone (ahl) is found to be the main component of quorum sensing (qs) in gram-negative bacteria and plays an important role in biofilm formation. little information is available regarding the role of ahl in biofilm formation in escherichia coli (e. coli). the purpose of this investigation was to biochemically detect and characterize ahl activity in biofilm-forming...

Abstract To improve the fire safety of epoxy resin (EP), two novel phosphorus–nitrogen flame retardants, which named as diphenyl allylphosphoramidate (DPCA) and N-allyl-P, P-diphenylphosphinic amide (DCA), were synthesized by acyl chloride reaction introduced into EP for fabricating composites. The combustion tests showed that incorporation 5 wt% DPCA or DCA led to exceptional limited oxygen in...

Some N¬-acyl-N'-aryl thiourea derivatives 4(a-f) have been prepared by the reaction of acyl halides ammonium thiocyanate and aryl amines. The structures of synthesized compounds have been characterized by IR, 1HNMR spectral studies. The synthesized compounds 5(a-f) have been screened for antibacterial activity. The effect of the structure of the investigated compounds on the antibacterial activ...