introduction: evaluating patient with acute scrotum is based on medical history (e.g. age), physical examination, blood tests, urine analysis and imaging studies. differential diagnosis may be difficult. efficacy of serum acute phase proteins in patients with acute scrotum was assessed in this study. materials and methods : 45 patients were recruited and allocated within three sub-groups; acute...

Acute phase C-reactive protein (CRP), raised in obesity and inflammation, is a main binding protein for leptin. It is assumed that CRP contributes to leptin confrontation by preventing leptin from crossing the blood-brain barrier (BBB). Here we defined how CRP cooperates with the BBB and whether it deters leptin from attainment CNS targets. CRP was constant in blood, but did not permeate the BB...

Involvement of the contact system of coagulation in the pathogenesis of various inflammatory diseases is suggested by reduced plasma levels of factor XII (Hageman factor) and prekallikrein generally considered to result from activation of the contact system. However, in many of these diseases patients develop an acute-phase response and, therefore, an alternative explanation for the decreased l...

BACKGROUND Serum amyloid P component (SAP) and acute phase proteins like C-reactive protein contribute to the clearance of apoptotic cells. This response is diminished in systemic lupus erythematosus (SLE). OBJECTIVES To analyse SAP concentrations in SLE in relation to disease activity, and investigate whether SAP reacts like an acute phase protein. METHODS SAP was measured in 40 patients w...

BACKGROUND Vitamin A deficiency adversely affects child morbidity and survival. This deficiency is estimated by measurement of plasma retinol concentrations, but because plasma retinol is reduced by clinical and subclinical infection, this proxy measure can lead to overestimation. Infection and trauma are accompanied by rises in concentrations of acute-phase proteins in plasma. We aimed to esti...

Acute phase proteins are serum constituents that change in concentrat ion after injury. This acute phase reaction may result in decreased serum levels (albumin), or more frequently, a 50-300% increased serum level (Ca or haptoglobin) (1, 2). H u m a n C-reactive protein (CRP) x is the classic acute phase reactant , its level increas ingas much as 500-fold after injury (for review see reference ...

A nephelometric assay of concanavalin-A binding of serum acute phase proteins (con-A binding) has been used in cross-sectional and sequential studies of disease activity in rheumatoid arthritis (RA). Con-A binding correlated well with blood viscosity, C-reactive protein, and other individual acute phase reactants in patients with active RA. Twenty-four patients were treated for 6 months with D-...