Leukocytes express a major sialoglycoprotein, leukosialin, of which the apparent molecular weight (mol wt) can be variable according to the differences in 0-glycans attached to this molecule. In the present study, we analyzed the structures of 0-glycans attached to leukosialin present in various T-lymphocytic leukemia cells. T-lymphoid cells from patients with acute T-lymphocytic leukemia expre...

Leukocytes express a major sialoglycoprotein, leukosialin, of which the apparent molecular weight (mol wt) can be variable according to the differences in 0-glycans attached to this molecule. In the present study, we analyzed the structures of 0-glycans attached to leukosialin present in various T-lymphocytic leukemia cells. T-lymphoid cells from patients with acute T-lymphocytic leukemia expre...

chronic lymphocytic leukemia (cll) and chronic myeloid leukemia (cml) are the most common leukemias of the elderly (>43 year). however, the sequential occurrence of cml followed by cll in the same patient is extremely rare. in our report, a 52-year-old female was diagnosed with cll (type of bone marrow (bm) infiltration was nodular and interstitial) and was treated with chlorambucil. 64 months ...

Background: Coexistence of Chronic lymphocytic lymphoma (CLL) to Acute lymphoblastic leukemia is extremely rare with only a few reported cases [1-5]. Chronic lymphocytic leukemia is a neoplasm of small monomorphic round to irregularly shaped lymphocytes of B-cell lineage. Adverse prognostic factors in CLL include flow cytometric expression of ZAP-70 and CD38 which are surrogate markers for the ...

characterized by a specific chromosomal marker (the Philadelphia chromosome, Ph’), a significant percentage of all morphologic types of leukemia, except possibly chronic lymphocytic leukemia, will demonstrate aneuploidy. This report describes the occurrence of acute lymphocytic leukemia (ALL) in a young man with a balanced C-G translocation, t(Cp; Gp+), a rare chromosomal abnormality not previo...

nucleostemin (ns), a stem cell-abundant nucleolar protein, is critical for maintaining the self-renewal and proliferative properties of normal and cancerous stem cells. recent data suggests that ns signaling is important for proliferation of t-cells and leukemia cells. this study was conducted to verify the role of ns in pathogenesis and treatment of t-cell acute lymphocytic leukemia (t-all). o...

Ferroptosis is a newly defined programmed cell death (PCD) process with the hallmark of accumulation iron-dependent lipid peroxidation, which more immunogenic over apoptosis. shows great potential as therapeutic target against acute kidney injury (AKI), cancers, cardiovascular diseases, neurodegenerative and hepatic diseases. Accumulating evidence has highlighted that ferroptosis plays an unneg...

Freshly isolated human leukemia cells have been shown in the past to display varying in vitro responses to phorbol diesters, depending on their cell type. Specific receptors for the phorbol diesters have been demonstrated on numerous different cells. This study was designed to characterize the receptors for phorbol diesters on leukemia cells freshly isolated from patients with different kinds o...