Bispecific monoclonal antibodies can be used in the activation of effec tor cells to lyse autologous tumor cells. We analyzed the activation of human T-cells in vitro with bispecific monoclonal antibodies, which were generated by hybridoma-hybridoma fusion. Preactivated allogeneic and autologous T-cells could be triggered to lyse tumoral B-cells in the pres ence of CD3 x CD19 bispecific antibod...

Human granulocyte colony-stimulating factor (G-CSF) rapidly loses the biological activity and the receptor binding capacity following radioiodination. We have made a mutein of human G-CSF, KW-2228, in which Thr-1, Leu-3, Gly-4, Pro-5, and Cys-I7 were respectively substi tuted with Ala, Thr, Tyr, Arg, and Ser; showed more potent G-CSF activity; and retained full biological activity and receptor ...

conclusions a high rate of 25% and 24.13% of hbv dna was detected among patients with hodgkin and non-hodgkin lymphoma, respectively. results three out of 12 (25%) hodgkin samples and seven out of 29 (24.13%) non-hodgkin showed positive hbv dna results. the results of sequencing revealed that the d genotype was predominant among the positive hbv patients. interestingly an unpredictable amino ac...

Abstract Lymphocytic choriomeningitis virus is an underreported cause of miscarriage and neurologic disease. Surveillance remains challenging because nonspecific symptomatology, inconsistent case reporting, difficulties with diagnostic testing. We describe a acute lymphocytic disease in person living HIV Connecticut, USA, identified by using quantitative reverse transcription PCR.

Chronic lymphocytic leukemia (CLL) is characterized by the accumulation of mature-appearing lymphocytes in blood, bone marrow, lymph nodes, and spleen with a median lymphocyte count of 20-30 × 10(9)/L at the time of diagnosis. In half of the patients, the lymphocyte count doubles over a period of 1-year and cyclic rise up to 50 × 10(9)/L can occur in untreated patients while in others the count...

ZAP-70 is a tyrosine kinase expressed in normal T cells and NK cells. Expression of ZAP-70 has been associated with poor prognosis in B-cell chronic lymphocytic leukemia and might be a surrogate marker for immunoglobin heavy chain (IGH) mutational status in that disease. Little is known about ZAP-70 expression in other hematologic malignant neoplasms. We examined 446 specimens representing a ra...

Previous studies from this laboratory have shown actin to be a major protein of human lymphocytes (Stark, R., Liebes, L. F., Nevrla, D., and Silber, R. Biochem. Med., 27: 200-206, 1982). We now report the purification to homogeneity and characteri zation of actin from blood lymphocytes of normal subjects and patients with chronic lymphocytic leukemia. The recovery of the purified protein was ab...

If one accepts the established fact that the adrenal steroids have regulatory powers over nor mal lymphoid tissue, it would seem reasonable to assume that the adrenal steroids may also regulate the immature cells of lymphocytic leukemia. Since the advent of the clinical use of cortisone and of ÕCTH in April, 1949, many studies on both animals and human beings have been attempted to determine w...

If one accepts the established fact that the adrenal steroids have regulatory powers over nor mal lymphoid tissue, it would seem reasonable to assume that the adrenal steroids may also regulate the immature cells of lymphocytic leukemia. Since the advent of the clinical use of cortisone and of ÕCTH in April, 1949, many studies on both animals and human beings have been attempted to determine w...