Thirty-seven patients with idiopathic thrombocytopenic purpura (ITP) were treated with a standard Helicobacter pylori eradication regimen irrespective of H. pylori infection. Our results indicate that platelet recovery results from the disappearance of H. pylori itself, and is mediated, in part, through suppression of anti-platelet autoantibody production.

Prof. Dr. Şinasi Özsoylu, Hacettepe Children’s Hospital, TR-06100 Ankara (Turkey) I have read with interest Barrios et al.’s paper on the ‘Treatment of Acute Idiopathic Thrombocytopenic Purpura with High-Dose Methylprednisolone and Immuno-globulin’ in a recent issue of the journal [1993;89:6-9]. The authors concluded that ‘the combined therapy resulted in rapid increments in the platelet counts...

Prof. Dr. Şinasi Özsoylu, Hacettepe Children’s Hospital, TR-06100 Ankara (Turkey) I have read with interest Barrios et al.’s paper on the ‘Treatment of Acute Idiopathic Thrombocytopenic Purpura with High-Dose Methylprednisolone and Immuno-globulin’ in a recent issue of the journal [1993;89:6-9]. The authors concluded that ‘the combined therapy resulted in rapid increments in the platelet counts...

The combination of idiopathic thrombocytopenic purpura (ITP) and chronic renal failure (CRF) is uncommon. This report highlights a case of renal transplantation in a patient with ITP. A 35-year-old man with ITP was admitted with uremic symptoms. A renal transplant and splenectomy was simultaneously performed. A prophylactic pneumococcous vaccination was performed and intravenous immunoglobulin ...

We studied the extent to which patient characteristics influenced outcome in childhood idiopathic thrombocytopenic purpura in a historical cohort of 289 children over a 20 year period (1968-87). Outcome was classified as acute or chronic depending on whether the platelet count had returned to normal (150 X 10(9)/l) by six months after diagnosis. Fifty three cases (18%) had chronic idiopathic th...

Besides cytopenia related to treatment, several hematological disorders such as anemia, abnormal platelet activity, thrombosis, presence of anticardiolipin or anti-neutrophil antibodies, cyclic neutropenia, and myelodysplasia, have been reported in patients with Crohn's disease (CD). The case we report here is the first one documenting the association of idiopathic thrombocytopenic purpura (ITP...

Platelet kinetic studies in idiopathic thrombocytopenic purpura (ITP) have shown that in a subgroup of patients a shortened mean platelet life (MPL) is associated with a decreased platelet production rate (PPR). Other methods of studying certain aspects of thrombocytopoiesis are the plasma concentrations of thrombopoietin and glycocalicin.

Regulation of thrombopoiesis: effects of the degree of thrombocytopenia on megakaryocyte ploidy and platelet volume. Blood 1987;70:177-85. 29. Stenberg PE, Levin J. Ultrastructural analysis of acute immune thrombocytopenia in mice: dissociation between alterations in megakaryocytes and platelets. Cazenave J-P, et al. Intrinsic impaired proplatelet formation and microtubule coil assembly of mega...

Cyclic thrombocytopenia (CTP) is a rare disorder characterized by periodic decreases and increases in platelet levels. Each cycle usually spans a period of 3-5 weeks. Clinical features are similar to those of idiopathic thrombocytopenic purpura (ITP), so patients are frequently misdiagnosed as having ITP. However, CTP usually does not respond to most treatments used in ITP such as corticosteroi...