Acute generalized exanthematous pustulosis (AGEP) is a dramatic generalized pustular rash of severe onset, which is considered a serious cutaneous adverse reaction to drugs. However, even though the clinical features are impressive and are often accompanied by systemic inflammation, it can be controlled quickly and safely by topical steroids subsequent to interruption of the offending drug. Her...

BACKGROUND Cutaneous pustular disorders include generalized pustular psoriasis (GPP) and acute generalized exanthematous pustulosis (AGEP). OBJECTIVE To identify differences between GPP and AGEP, here we immunohistochemically evaluated interleukin (IL)-36 and the IL-23/Th17 axis. METHODS This retrospective comparative immunohistochemical study was completed using 11 biopsies of 11 cases of ...

Acute generalized exanthematous pustulosis is a rare drug-induced eruption that is characterized by acute, nonfollicular sterile pustules on an erythematous and edematous base. The most frequently implicated drugs are beta-lactam antibiotics. Hydroxychloroquine has been widely used to treat dermatologic and rheumatologic diseases and has been reported as a rare cause of acute generalized exanth...

Acute localized exanthematous pustulosis is a localized variant of acute generalized exanthematous pustulosis, which is characterized by the eruption of multiple scattered pustules following drug administration. A 72-year-old woman presented with multiple erythematous pustules on her face, which had appeared two days after using cefoperazone and sodium sulbactam. Histopathological findings show...

Background. Acute generalized exanthematous pustulosis (AGEP) is a rare and serious adverse reaction of terbinafine. Understanding AGEP terbinafine primarily based on case reports. The purpose to explore the clinical characteristics terbinafine-induced AGEP, provide reference for diagnosis treatment. Methods. Case reports original studies were retrieved by searching Chinese English databases fr...

BACKGROUND Acute generalized exanthematous pustulosis (AGEP) is a rare severe pustular reaction pattern with a typical clinical picture. OBJECTIVES To characterize the histopathological features of AGEP in a large series of cases with a validated diagnosis. METHODS; A multinational retrospective histopathological study was conducted. It included 102 hospitalized patients (recruited within the...

BACKGROUND Acute generalized exanthematous pustulosis (AGEP) is a disease characterized by the rapid occurrence of many sterile, nonfollicular pustules usually arising on an oedematous erythema often accompanied by leucocytosis and fever. It is usually attributed to drugs. OBJECTIVES To evaluate the risk for different drugs of causing AGEP. PATIENTS AND METHODS A multinational case-control ...

© 2011 The Authors. doi: 10.2340/00015555-1116 Journal Compilation © 2011 Acta Dermato-Venereologica. ISSN 0001-5555 Acute generalized exanthematous pustulosis (AGEP) is a disease characterized by the rapid onset of numerous small, non-follicular, sterile pustules on an erythematous base associated with oedema, which usually begins in intertriginous areas (1). Fever over 38oC and peripheral blo...