Two patients with acute disseminated encephalomyelitis after repeated injection of extracts from several different plants are described. There was no evidence of prior infection or vaccination. Both patients recovered rapidly after treatment with methylprednisolone. Acute disseminated encephalomyelitis should be considered a rare complication of parenteral therapy with herbal extracts.

Acute disseminated encephalomyelitis (ADEM) is a monophasic, postinfectious or postvaccineal acute infl ammatory demyelinating disorder of central nervous system (CNS).[1,2] The pathophysiology involves transient autoimmune response directed at myelin or other self-antigens, possibly by molecular mimicry or by nonspecifi c activation of autoreactive T-cell clones.[3] Histologically, ADEM is cha...

Though the indication mentioned for resorting to plasmapheresis in the report is the unaffordability of intravenous immunoglobulin (IVIG) therapy, I wish to highlight other important reasons for preferring plasmapheresis over IVIG. Firstly, IVIG is known to exert its immunomodulatory effects for a prolonged period of time. The mean duration of action of IVIG is 53 days and the half life of immu...

Objective. To describe the epidemiologic, clinical, neuroimaging, and laboratory features; treatment; and outcome in a cohort of children with acute disseminated encephalomyelitis (ADEM). Methods. A 6-year retrospective chart review of children with the diagnosis of ADEM was conducted. Results. Eighteen cases were identified. Sixteen patients (88%) presented in either winter or spring. Thirteen...

OBJECTIVE To describe the epidemiologic, clinical, neuroimaging, and laboratory features; treatment; and outcome in a cohort of children with acute disseminated encephalomyelitis (ADEM). METHODS A 6-year retrospective chart review of children with the diagnosis of ADEM was conducted. RESULTS Eighteen cases were identified. Sixteen patients (88%) presented in either winter or spring. Thirtee...

Fusarium species are saprophytic molds which cause disseminated or localized infections in humans. Disseminated Fusarium infection can cause significant morbidity and mortality in immunocompromised patients. We present a case of disseminated fusariosis caused by Fusarium verticillioides in a patient with acute lymphoblastic leukemia and successfully treated using both liposomal amphotericin B a...