introduction: fournier's gangrene or necrotizing fasciitis of external genitalia is a medical emergency. it was reported in cases of acute promyelocytic leukemia (apl) before and during induction therapy with all- trans retinoic acid (atra).we present a case of apl that developed fournier's gangrene   during atra therapy.

a-10-year-old girl was referred to our department for multiple hyperpigmented plaques. one  week  previously,  she  had  been  given  one  suppository  of  acetylsalicylic acid  – phenobarbital for fever. twelve hours after the drug intake the child developed pruritic red plaques on the left thigh. six weeks after resolution of the acute reaction, patch tests were performed separately, with phe...

Changes in extra and intracellular neurotransmitter amino acids concentration in the early stage of acute cerebral ischemia have been reported. In this the study, serum level of gamma aminobutyric acid (GABA) and L-Arginine in acute ischemic stroke patients was assessed. 60 patients with acute ischemic stroke and sixthy healthy volunteers as a control group were assessed. Serum GABA was measure...

BACKGROUND Impact of high level of uric acid on stroke is still controversial. We conducted this study to investigate the relationship between acute ischemic non-embolic stroke and serum levels of uric acid. METHODS This was a case-control study on patients with acute ischemic non-embolic stroke in Rafsanjan, Iran. The control group consisted of normal persons who were similar to the case gro...

Acute interstitial nephritis in a patient taking tienilic acid A patient taking the uricosuric diuretic tienilic acid or ticrynafen (2,3-dichloro-4-(2-thienyl-carbonyl) phenoxyacetic acid)-marketed as Selacryn, (Smith, Kline and French Laboratories 62698) developed acute renal failure due to acute allergic interstitial nephritis. Case report A 61-year-old housewife of Lithuanian extraction had ...

Acute pseudoseptic arthritis is a very rare complication that is associated with intra-articular hyaluronic acid injections, which normally involve minimal risk. The most common adverse events that are caused by hyaluronic acid injections are inflammatory reactions or flares at the injection site. In this study, we described three cases of acute pseudoseptic arthritis that was caused by hyaluro...

Following major tissue injury, hyaluronic acid production increases as a rapid response survival mechanism. Increased hyaluronic acid production and turnover are often associated with increased hyaluronidase activity, the enzyme that degrades hyaluronic acid. We investigated whether hyaluronic acid and hyaluronidase can be used as non-invasive markers of acute disease activity in hepatitis C by...

Peptic ulcer disease (PUD) is a sore in the lining of stomach or duodenal mucosa. This study was aimed at evaluating antiulcer activity aqueous extract Nigella sativa (black seed) and its constitutents. The pharmacognostic properties dry seeds were determined. extracted using two methods digestion hydro-distillation. acute toxicity, phytochemical constituents evaluation performed on ethanol-ind...