Cabergoline (CAB), the first-line drug for treatment of prolactinomas, is effective in suppressing prolactin hypersecretion, reducing tumor size, and restoring gonadal function. However, mechanisms for CAB-mediated tumor shrinkage are largely unknown. Here we report a novel cytotoxic mechanism for CAB. CAB induced formation of autophagosome in rat pituitary tumor MMQ and GH3 cells at the early ...

Taking a light truck for study, using finite element method and virtual prototyping technology to establish a vehicle’s rigid model and rigid-flexible coupling model considered cab elasticity. On a random road with cab suspension of rubber and semi-floating we made a simulation analysis on vehicle ride comfort, taking into account acceleration power spectral density and weighted acceleration rm...

Cabergoline (CAB) is widely used for the medical treatment of pituitary tumors, particularly those associated with hormone hypersecretion. Whether treatment with CAB is associated with an increased risk of clinically relevant cardiac valve disease in patients with pituitary tumors is still debated. In most studies, CAB has been found not associated with an increased risk of significant valvulop...

DET1 is a pleiotropic regulator of Arabidopsis development and controls the expression of many light-regulated genes. To gain a better understanding of the mechanism by which DET1 controls transcription from light-regulated promoters, we identified elements in the chlorophyll a/b-binding protein 2 (CAB2) promoter that are required for DET1-mediated expression. Using a series of reporter constru...

Abstract This study investigates whether quasi-random surface vertical vorticity is sufficient for tornadogenesis when combined with an updraft typical of tornadic supercells. The viability this pathway could mean that a coherent process to produce well-organized rather unimportant. Highly idealized simulations are used establish random noise as possible seed the production tornado-like vortice...

BACKGROUND Dopamine agonist resistance in prolactinoma is an infrequent phenomenon. Doses of cabergoline (CAB) of up to 2.0 mg/week are usually effective in controlling prolactin (PRL) secretion and reducing tumor size in prolactinomas. The clinical presentation, management, and outcome of patients that are not well controlled by such commonly used doses of CAB-resistant patients are poorly und...

BACKGROUND Community advisory boards (CAB) are proposed as one mechanism to carry out successful community based participatory research (CBPR), but the presence of CABs may be insufficient to optimize academic-community partnerships. METHODS We conducted semi-structured interviews with minority members of a CAB partnered with a HIV/AIDS research center and identified three themes. RESULTS F...