نتایج جستجو برای: active crohns disease
تعداد نتایج: 1875230 فیلتر نتایج به سال:
BACKGROUND Development of inflammatory bowel disease (IBD) involves the interplay of environmental and genetic factors with the host immune system. Mechanisms contributing to immune dysregulation in IBD are not fully defined. Development of novel therapeutic strategies is focused on controlling aberrant immune response in IBD. Current IBD therapy utilizes a combination of immunomodulators and b...
The epoxygenase CYP2J2 has an emerging role in inflammation and vascular biology. The role of CYP2J2 in phagocytosis is not known and its regulation in human inflammatory diseases is poorly understood. Here we investigated the role of CYP2J2 in bacterial phagocytosis and its expression in monocytes from healthy controls and Crohns disease patients. CYP2J2 is anti-inflammatory in human periphera...
BACKGROUND In Crohn's disease high tissue expression and serum levels of chemokines and their receptors are known to correlate with disease activity. Because statins can reduce chemokine expression in patients with coronary diseases, we wanted to test whether this can be achieved in patients with Crohn's disease. METHODOLOGY/PRINCIPAL FINDINGS We investigated plasma levels of chemokines (CCL2...
Abstract Peritoneal Tuberculosis (PTB) is a rare extra-pulmonary manifestation of Mycobacterium tuberculosis infection. It usually presents with non-specific symptoms that can mimic other intra-abdominal pathology. Therefore, high index suspicion needed for diagnosis and early treatment PTB. Some the conditions in young patients may have similar presentations to PTB include Crohns’ disease, ova...
Abstract Background Liver transplantation (LT) remains the only therapeutic option for patients with primary sclerosing cholangitis (PSC) who develop biliary tract complications or cirrhosis. Around 50-80% of PSC have IBD which represent phenotypically unique disease. Patients are prone to negative effects liver disease and immunosuppression, unpredictable course both diseases development neopl...
We welcome the interest shown by colleagues in Rome about the Ulcerative Colitis Endoscopic Index of Severity [UCEIS]1,2 and their suggestion that it might be enhanced by segmental scoring at full colonoscopy. When the score was being developed,3 the international working group felt that a major goal was for the score to be simple, not to replicate the relative complexity of endoscopic scoring ...
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