Replicative senescence is a natural barrier to cellular proliferation that is triggered by telomere erosion and dysfunction. Here, we demonstrate that ATM activation and H2AX-gamma nuclear focus formation are sensitive markers of telomere dysfunction in primary human fibroblasts. Whereas the activated form of ATM and H2AX-gamma foci were rarely observed in early-passage cells, they were readily...

O objetivo deste estudo é o de analisar a previsão focos calor (FC) na Região Metropolitana Maceió (RMM) utilizando Rede Neural Artificial (RNA). Foram usados neste os dados no período 1999 2019, disponíveis Banco Dados Queimadas (BDQueimadas). A foi feita com base RNA não linear autorregressiva (NAR) FC sendo entrada e alvo. As previsões se basearam função ativação Tangente Hiperbólica Sigmoid...

Previous studies have analyzed the lymphoid and myeloid foci within the gingival mucosa in health and chronic periodontitis (CP); however, the principal APCs responsible for the formation and organizational structure of these foci in CP have not been defined. We show that in human CP tissues, CD1a(+) immature Langerhans cells predominantly infiltrate the gingival epithelium, whereas CD83(+) mat...

Looking at still images of body parts in situations that are likely to cause pain has been shown to be associated with activation in some brain areas involved in pain processing. Because pain involves both sensory components and negative affect, it is of interest to explore whether the visually evoked representations of pain and of other negative emotions overlap. By means of event-related func...

Background Inferoseptal process of the left ventricle (ISP-LV) might be a source idiopathic ventricular arrhythmias. In these cases, ectopic foci are accessible from LV endocardium, epicardially middle cardiac vein as well right atrium (RA). This study reports series patients with premature contractions (PVCs) arising ISP-LV that were successfully ablated following access different structures. ...

In proliferating cells, DNA synthesis must be performed with extreme precision. We show that groups of replicons, labeled together as replicon clusters, form stable units of chromosome structure. HeLa cells were labeled with 5-bromodeoxyuridine (BrdU) at different times of S phase. At the onset of S phase, clusters of replicons were activated in each of approximately 750 replication sites. The ...

DNA damage can activate the oncosuppressor protein ataxia telangiectasia mutated (ATM), which phosphorylates the histone H2AX within characteristic DNA damage foci. Here, we show that ATM undergoes an activating phosphorylation in syncytia elicited by the envelope glycoprotein complex (Env) of human immunodeficiency virus-1 (HIV-1) in vitro. This was accompanied by aggregation of ATM in discret...

Abstract Rumination, as a clinical manifestation and pathogenic factor of depression, has long been the focus psychological research regarding its causes ameliorating approaches. Behavioral studies have shown that rumination is related to inhibitory control deficits, which provides ideas for reducing it. However, neural relationship between them not clearly discussed. In this study, we first us...

We have analyzed the geometry, geography, and functional organization of human cerebral cortex using surface reconstructions and cortical flat maps of the left and right hemispheres generated from a digital atlas (the Visible Man). The total surface area of the reconstructed Visible Man neocortex is 1570 cm (both hemispheres), ;70% of which is buried in sulci. By linking the Visible Man cerebru...

We have analyzed the geometry, geography, and functional organization of human cerebral cortex using surface reconstructions and cortical flat maps of the left and right hemispheres generated from a digital atlas (the Visible Man). The total surface area of the reconstructed Visible Man neocortex is 1570 cm2 (both hemispheres), approximately 70% of which is buried in sulci. By linking the Visib...