production and approval of trastuzumab (herceptin®) for the treatment of metastatic breast cancer (mbc) was a millstone in antibody-based targeted therapy in the cancer treatment. however, despite the early success in the clinical trials, trastuzumab failed to appreciate the initial attraction due to development of resistance to the drug. the majority of patients who benefit from the drug acqui...

in this paper, we give a classification of non simply connected seven dimensional reimannian manifolds of constant positive curvature which admit irreducible cohomogeneity-one actions. we characterize the acting groups and describe the orbits. the first and second homo-topy groups of the orbits have been presented as well.

it was thought previously that cardiac muscle gap junctions provide low-resistance connections between cells and permit the local-circuit current to flow. some evidences show that myocardial cells may not require low-resistance connections for successful propagation of the action potential (ap). it seems that some other types of mechanisms must be involved in ap propagation. in this article, we...

introducation: emotion regulation and thought-action fusion (taf) are among the most important components which cause psychological disorders. the present study aimed to predict somatoform disorder regarding the emotion regulation and taf in female students of the savadkuh county. methods:   in this descriptive correlation study, 110 middle school female students in the city of savadkuh in the ...

certainly, methodology of political jurisprudence (feghe seyasi) is closely related to “ejtehad”( practicing religious jurisprudence) . so, methodologically, understanding characteristics of political jurisprudence , requires understanding ejtehad. and ejtehad ,in turn, requires understanding the relations of it with “language” and “action” .therefor, understanding the two relations, clears the...

human free acts have always been one of most difficult but important issues in philosophical debates. in this paper, i will try to provide an interpretation of these acts and argue for human free will and freedom. to this end, i will first, disucss the distinction of necessary acts from free acts, and then will argue for the free will, and its relation to free acts and freedom. finally, some co...