Mycetoma is a chronic suppurative disease of the skin and subcutaneous tissue, characterized by a symptomatic triad: tumor, fistulas and grains. It can be caused by fungi (eumycetoma) and bacteria (actinomycetoma), with similar clinical features. Diagnosis is based on the clinical presentation and identification of the etiological agents in the tissue, by mycological/bacteriological, histopatho...

BACKGROUND Nocardia are organisms that can escape the effects of both immune response and antimicrobial agents, due to their potential capacity to grow intracellularly. In previous studies, we found that experimental oxazolidinones, DA-7157 and DA-7218, are active both in vitro and in vivo. OBJECTIVES In this study, we compare the ability of linezolid, DA-7157 and DA-7218 to inhibit intracell...

Mycetoma is a chronic granulomatous infection of the subcutaneous tissue caused by true fungi or higher bacteria; hence, it is classified as eumycetoma or actinomycetoma, respectively (5). Mycetoma is endemic in (sub)tropical areas, and the Sudan seems to be the mycetoma homeland, with hundreds of new patients attending specialized clinics each year. Mycetoma pathogens such as the fungus Madure...

mycetoma is a chronic and pustular infection usually involves foot. mycetoma in iran is not common and most cases have been reported from the south and north of iran. the objective of present study was to review the mycetoma and the distribution of its etiologic agents in iran. moreover, a 60-year-old woman with actinomycetoma lesions in her left foot was presented. direct smear of the grains s...

Mycetoma is a chronic, progressive, and destructive disease primarily caused by actinomycetes. This is a report of 4 cases of actinomycotic mycetomas studied in our hospital during the last five years. The patients included 2 men, 56 and 42 years old, and 2 women, 31 and 52 years old, from Khuzestan province located in the south west of Iran. Clinically all patients presented with mycetoma synd...

Mycetoma is a chronic progressive granulomatous infection characterized by a painless swelling, development of sinuses that discharge pus and grains of different colors. It will ultimately involve bone that shows cavities in a plain x-ray. It is important to determine whether the cause is bacterial (Actinomycetoma) or fungal (Eumycetoma) because the former is treated by antibiotics and the latt...

Redox-active drugs are the mainstay of parasite chemotherapy. To assess their repurposing potential for eumycetoma, we have tested a set nitroheterocycles and peroxides in vitro against two isolates Madurella mycetomatis, main causative agent eumycetoma Sudan. All compounds were inactive except niclosamide, which had minimal inhibitory concentrations around 1 µg/mL. Further tests with niclosami...

An experimental model of infection with Nocardia brasiliensis, used as an example of a facultative intracellular pathogen, was tested. N. brasiliensis was injected into the rear foot pads of BALB/c mice to establish an infection. Within 30 days, infected animals developed a chronic actinomycetoma infection. Batch cultures of N. brasiliensis were used to purify P61, P38, and P24 antigens; P61 is...