Graft copolymer networks of poly(methacrylic acid-g-ethylene glycol) exhibiting pHdependent swelling behavior due to the formation of interpolymer complexes were prepared by free radical solution polymerization of methacrylic acid and poly(ethylene glycol) monomethacrylate. Dynamic swelling studies established the swelling/deswelling process due to hydrogen bonding. Additionally, the effects of...

The rheological behavioral changes that occurred during the synthesis of an interpolyelectrolyte complex (IPEC) of methacrylate copolymer and sodium carboxymethylcellulose were assessed. These changes were compared with the rheological behavior of the individual polymers employing basic viscosity, yield stress, stress sweep, frequency sweep, temperature ramp as well as creep and recovery testin...

Urethane copolymer sorbent materials that incorporate β-cyclodextrin (CD) have been prepared and their sorption properties with chlorinated aromatic compounds (i.e., pentachlorophenol, 2,4-dichlorophenol and 2,4-dichlorophenoxy acetic acid) have been evaluated. The sorption properties of granular activated carbon (GAC) were similarly compared in aqueous solution at variable pH conditions. The s...

Copolymer thin films with two types of functional groups have excellent performance as sensors, for example. The formation and deposition allyl alcohol-acrylic acid copolymer by pulsed high frequency plasma is a complex process. As usual, the chemical composition top surface was investigated XPS FTIR measurements. Furthermore, contact angle measurements water were used to characterise hydrophil...

A total of one hundred twenty-one (121) adult male and female subjects completed a 6-month, double-blind clinical study comparing the effect on supragingival plaque formation and gingivitis of a dentifrice containing 0.3% Triclosan and 2.0% of a copolymer of methoxyethylene and maleic acid to a placebo dentifrice. Both the Triclosan/copolymer and placebo dentifrices contained 0.243% sodium fluo...

Since hyaluronic acid (HA) receptor such as CD44 is over-expressed at sites of cancer cells, HA can be used as a targeting vehicles for anti-cancer drugs. The aim of this study is to synthesize block copolymer composed of hyaluronic acid and poly(ε-caprolactone) (HAPCL) and to fabricate polymeric micelles for anticancer drug targeting against CD44 receptor of tumor cells. Chemical composition o...

INTRODUCTION Acrylic resins containing acrylic acid (AA), methyl methacrylate (MMA) or acrylic–methacrylic copolymer are the most commonly used polymeric materials for biomedical and pharmaceutical applications owing to their hydrophilicity and biocompatibility.1–4 Recently, a new polyvinyl alcohol (PVA) copolymer designed by copolymerizing AA and MMA with PVA was successfully developed as a ca...

Biocompatible oils are used in a variety of medical applications ranging from vaccine adjuvants to vehicles for oral drug delivery. To enable such nonpolar organic phases to serve as reservoirs for delivery of hydrophilic compounds, we explored the ability of block copolymer micelles in organic solvents to sequester proteins for sustained release across an oil-water interface. Self-assembly of ...

Nanoparticle (NP) delivery systems for small interfering RNA (siRNA) that have good systemic circulation and high nucleic acid content are highly desired for translation into clinical use. Here, a family of cationic mucic acid-containing polymers is synthesized and shown to assemble with siRNA to form NPs. A cationic mucic acid polymer (cMAP) containing alternating mucic acid and charged monome...

Copolymer 1 (Cop 1, Copaxone [Teva Marion Partners, Kansas City, Missouri, USA]), a random amino acid copolymer of tyrosine (Y), glutamic acid (E), alanine (A), and lysine (K), reduces the frequency of relapses by 30% in relapsing-remitting multiple sclerosis (MS) patients. In the present study, novel random four-amino acid copolymers, whose design was based on the nature of the anchor residues...