The crystal structure of a complex between the bimolecular human telomeric quadruplex d(TAGGGTTAGGGT)2 and the experimental anticancer drug BRACO-19, has been determined, to 2.5 A resolution. The binding site for the BRACO-19 molecule is at the interface of two parallel-folded quadruplexes, sandwiched between a G-tetrad surface and a TATA tetrad, and held in the site by networks of water molecu...

Only a very small number of the known substances is strongly carcinogenic. This indicates that carcinogenicity is linked to different qualities which all must be present to produce cancer. The various chemical reactions or qualities brought into relation with carcinogenicity reflect one or more of these factors. None of them seems to comprise all involved parameters. At the same time, none of t...

In the crystal structure of the title compound, C(21)H(15)BrNO(2) (+)·CF(3)SO(3) (-), adjacent cations are linked through C-Br⋯π and π-π contacts [centroid-centroid distance = 3.744 (2) Å], and neighbouring cations and anions via C-H⋯O, C-F⋯π and S-O⋯π inter-actions. The acridine and benzene ring systems are oriented at a dihedral angle of 18.7 (1)°. The carb-oxy group is twisted at an angle of...

Sir,?I have read with great interest the article, 'A Case of Giardiasis' by H. S. Andleigh, in the June 1942 number of the Indian Medical Gazette. The author reports the striking results of treating a case of giardiasis with atebrin but does not offer any explanation for this, at first sight, surprising result. As this article may lead to further experiments with this method I may perhaps be pe...

A novel molecular switch based on the supramolecular complex of 2,4,6-triarylpyridine modified β-cyclodextrin and acridine red was successfully constructed in aqueous solution, displaying the controlled photophysical behaviors by the effect of supramolecular positive cooperativity and fluorescence resonance energy-transfer process.