Heat stroke is a potentially fatal disorder that's caused by an extreme elevation in body temperature. We report here an unusual case of multiple organ failure that was caused by classical, nonexertional heat stroke due to taking a warm bath at home. A 68 year old diabetic man was hospitalized for loss of consciousness. He was presumed to have been in a warm bath for 3 hrs and his body temperat...

Acinetobacter baumanii is a Gram-negative, non-fermenting, oxidase-negative and non-motile coccobacillus, [1]. It can survive in water, soil, surface of skin and hospital environment. It cause a series of opportunistic infections such as epidemic pneumonia, skin and soft tissue infections, bacteraemia, urinary tract infections and septicemia app:addword:septicemia in immunocompromised patients,...

Untreatable bacterial infections (“the post-antibiotic era”) are far more likely to emerge in companion animals than in food animals, and have already arrived in the form of the multi-drug resistant (MDR) ESKAPE pathogens, the scourge of hospitals. These highly resistant, and in some cases hospital-adapted pathogens, are Enterococcus faecium, methicillin-resistant Staphylococcus pseudintermediu...

Pyrazinamidase (PncA) activates the first-line antituberculous drug pyrazinamide into pyrazinoic acid. The crystal structure of the Mycobacterium tuberculosis PncA protein has been determined, showing significant differences in the substrate binding cavity when compared to the pyrazinamidases from Pyrococcus horikoshii and Acinetobacter baumanii. In M. tuberculosis, this region was found to hol...

In recent decades, emerging bacterial resistance is defying the efficacy of currently available antibiotics. Of the approximate 1.7 million hospital acquired infections in the US annually, a staggering 350,000 infections can be attributed to just a few multi-drug resistant pathogens [1-3]. Current consensus indicates Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobac...

The emergence and spread of multidrug-resistant bacteria (MDR) are major public health issues worldwide. objective this study is to evaluate the microbiological efficacy tigecycline against multi-drug-resistant explore its potential place in clinical practice. A retrospective was carried out over 7 years, from January 2015 December 2021, at Avicenne Military Hospital. Were collected all bacteri...

Multidrug-resistant (MDR) bacteria have become a severe threat to community wellbeing. Conventional antibiotics are getting progressively more ineffective as a consequence of resistance, making it imperative to realize improved antimicrobial options. In this review we emphasized the microorganisms primarily reported of being resistance, referred as ESKAPE pathogens (Enterococcus faecium, Staphy...

This Letter reports a family of novel antimicrobial compounds obtained by combining peptide library screening with structure-based design. Library screening led to the identification of a human LL-37 peptide resistant to chymotrypsin. This d-amino-acid-containing peptide template was active against Escherichia coli but not methicillin-resistant Staphylococcus aureus (MRSA). It possesses a uniqu...

Acinetobacter baumanii has emerged as an important opportunistic pathogen within the hospital environment, being able to colonize and produce infections in ventilator associated pneumonia, secondary meningitis, urinary tract, septicaemia and other conditions in intensive care unit (ICU) patients. It is also causing infections in other immunocompromised patients, including burns patients. Antimi...