OBJECTIVE To study the effects of the somatostatin analog octreotide on gastric mucosal function and histology during short-term (3 months) preoperative treatment in patients with acromegaly. DESIGN Open design clinical study. METHODS 10 patients were studied before treatment with octreotide (pre-tx), on day 1 of 300 microg octreotide/day (d300), after 1 week on 300 (w300), 600 (w600) or 15...

This is an in vitro study to evaluate five different commercially available citrus fruits: viz., Sweet orange (Citrus sinences Osbeck), Grape [Citrus maxima (J. Buruan) Merrile], Lemon [Citrus limon (Burn F.) and Lime (Citrus aurantifolia Swingle. Evaluation of their pHs and neutralizable acidity were made. A 50 mL of each fruit was prepared by juice press. Initial pH was measured in triplicate...

OBJECTIVE To determine the dental hazards associated with sports supplement drinks by investigating the chemicophysical properties of eight brands of sports drinks. METHODS The pH and titratable acidity against 0.1 M NaOH was measured. Calcium, phosphate, and fluoride concentrations and viscosities of Carbolode, Gatorade, High Five, Isostar, Lucozade Sport Lemon, Lucozade Sport Orange, Maxim,...

Twenty four hour intragastric acidity was measured in nine patients with duodenal ulcer before and after one week of treatment with oral omeprazole 30 mg daily, a drug that inhibits gastric secretion by inhibition of parietal cell H+K+ adenosinetriphosphatase (ATPase). Omeprazole virtually eliminated intragastric acidity in all patients: the median 24 hour intragastric pH rose from 1.4 to 5.3 a...

Large-scale human activities including the extensive combustion of fossil fuels have caused acidification of freshwater systems on a continental scale, resulting in reduced species diversity and, in some instances, impaired ecological functioning. In regions where acidity is natural, however, species diversity and functioning seem to be less affected. This contrasting response is likely to have...

Desirability and good background of yogurt have led the manufacturers to use this product mostly for producing milk-based probiotic products. The aim of this study was to evalutate the effect of a mixture of prebiotics including oligofructose, lactulose, and inulin on physicochemical properties (pH value, acidity, and syneresis) of synbiotic yogurt containing lactobacillus casei. Pasteurized mi...

We have developed a way to measure cell surface pH by positioning a pH-sensitive fluorescent dye, seminaphtharhodafluor (SNARF), conjugated to the pH low insertion peptide (pHLIP). It has been observed that many diseased tissues are acidic and that tumors are especially so. A combination of effects acidifies tumor cell interiors, and cells pump out lactic acid and protons to maintain intracellu...

Anti-angiogenic treatments targeting the vascular endothelial growth factor or its receptors have shown clinical benefits. However, impact on long-term survival remains limited. Solid tumors display an acidic microenvironment that profoundly influences their biology. Consequences of acidity on endothelial cells and anti-angiogenic therapies remain poorly characterized and hence are the focus of...

Purpose Malignant tumors are acidic. The extracellular pH of tumors ranges from 6.5-6.9 versus 7.2-7.4 in normal tissue. Acid-producing tumors are more invasive and exhibit a greater metastatic potential. Tumor acidity is toxic to the surrounding tissue, induces the breakdown of the basement membrane around the tumor, and increases expression and activity of metastatic effectors. Therefore, it ...