A new series of 2-(ortho & para substituted phenoxy)1-(3-(3-chloro-4-methoxyphenyl)-5-(substituted phenyl)-4,5dihydropyrazol-1-yl)ethanone were synthesized. Ortho and para substituted phenol was refluxed with ethylchloroacetate in dry acetone in presence of anhydrous potassium carbonate to yield ethyl (ortho & para substituted phenoxy) acetate (1). The substituted ester on reaction with hydrazi...

2-Morpholine-4ylethyl-3H -1,2,4-triazole-3-ones (2a, 2b) were obtained from the condensation between the corresponding ethoxycarbonylhydrazones and 2-morpholinoethanamine. 2a was converted to acetohydrazide (4) via the formation of an ester derivative (3). Treatment of 2a and 2b with several aryl sulfonyl chlorides afforded the corresponding 2-arylsulfonyl-1,2,4-triazole-3-ones (5a-c and 6). Th...

1-[(N-acetyl)2,3-dichloroanilinomalonyl]3,5-dimethyl-4-(unsubstituted/substituted phenylazo) pyrazoles have been synthesised in 34 to 65% yield, by the reaction of 2,4-diketo-3(unsubstituted/substituted phenylazo) pentane with Ethyl-2-[(N-acetyl)2,3-dichloroanilido] acetohydrazide. Pyrazoles are brown and yellow colour solids, having high melting points. Identity of products has been establishe...

We have synthesized a new series of bis-amide and hydrazide-containing derivatives of malonic acid and thiophenoladducts of acidhydrazones by the reaction of 2-[(N-benzoyl) 2, 5-dichloroanilido] acetohydrazide with various Carbonyl Compounds in 40 to 65% yield. Newly prepared compounds have been tested for their anti-bacterial activity against gram positive bacteria S.albus, S.aureus and gram n...

Diclofenac sodium has been used for its anti-inflammatory actions for about 28 years, but since all the non-steroidal anti-inflammatory drugs (NSAIDs) suffer from the lethal gastro intestinal (GI) toxicities, diclofenac sodium is not an exception. The free -COOH group is thought to be responsible for the GI toxicity associated with all traditional NSAIDs. In the present research, the main motto...

Several new pyrazolo[4,3-b] pyridines 7a, b were prepared by reacting arylidenemalononitriles 1a, c or 1i, j with 4-nitrosoantipyrine 4. Reacting 1a, b, d with 4-azidomethylcarbonylantipyrine 8 give 2-aminopyrrole 14. Pyrano[3,2-c] quinolines 20a, b and 23 were obtained by reacting 4-hydroxyquinoline 15 with 1g, h, 2b respectively. Reaction of 1 with naphthalenediols 24, 27 and 29 yield naphtho...

A new series of 1-[(2, 5-dichloroanilinomalonyl)-3-(N-2’-cyanoethyl)-2-(Ncinnamoyl) 2, 5-dichloroanilino)]-5phenyl pyrazoline have been synthesized in 49 to 66% yield, by the reaction of N-cinnamoyl-N-2’-cyanoethyl-2,5dichloroaniline with 2-[(Ncinnamoyl) 2,5-dichloroanilido] acetohydrazide. Pyrazolines are yellow, cream and brown color solids, having high melting points. Identity of these produ...

A (pyridazinyl)acetate derivative was reacted with thiosemicarbazide and hydrazine hydrate to yield spiropyridazinone and acetohydrazide derivatives, respectively. The acetohydrazide derivative was used as a starting material for synthesizing some new heterocyclic compounds such as oxoindolinylidene, dimethylpyrazolyl, methylpyrazolyl, oxopyrazolyl, cyanoacetylacetohydrazide and oxadiazolylacet...

Ethyl-1H-benzotriazol-1-acetate 2 was prepared by reacting 1H-benzotriazole 1 in alcohol with ethyl bromoacetate in presence of anhydrous potassium carbonate, which was treated with hydrazine hydrate under reflux for 1824 hours to obtain the intermediate 1H-benzotriazole-1-acetic acid hydrazide 3. This compound on Schiff’s reaction with aromatic aldehydes in presence of solvent mixture yielded ...

A series of new 1-[(2, 3-dichloroanilinomalonyl)]-3-(N-2’-cyanoethyl-N-2, 3-dichloroanilino)-5phenyl pyrazoline have been synthesized in 48 to 77% yield, by the reaction of N-cinnamoyl-N-2’cyanoethyl-2, 3-dichloroaniline with Ethyl-2-(2,3-dichloroanilido) acetohydrazide. Pyrazolines are yellow, cream and brown color solids, having high melting points. Identity of these products has been establi...