Novel aryl substituted pyrazaboles 2-9 with direct and acetylenic linkages were synthesized by Pd-catalyzed Suzuki or Sonogashira cross-coupling reactions. Their structural, thermal, and photonic properties were investigated. The results show that the aryl pyrazaboles 2-9 exhibit good thermal stability, high fluorescence quantum yield, and tunable photophysical properties. The aryl substituted ...

A series of benzyl propargyl ethers were synthesized and tested as inhibitors of 5-lipoxygenase, the key enzyme involved in leukotriene biosynthesis. Among these, optimum activity was displayed by 1-(2-heptynyloxymethyl) benzene 12 (IC50 1.2 microM). Addition of carboxyl group at the end of the alkyl side chain attached to the acetylenic group abolished the inhibition. Selective reduction of th...

Graphyne, a novel carbon allotrope, is a two-dimensional lattice of sp2+sp1 hybridization-type carbon atoms, similar to graphene. The initiation and development of wrinkles in single-layer graphynes (α-, β-, γ-, and 6, 6, 12-graphyne) subjected to in-plane circular shearing are investigated. In comparison with graphene, wrinkle pattern and profile characterization in relation to wave number, wa...

Phenylacetylene and biphenylacetylene are oxidized by cytochrome P-450 to the corresponding arylacetic acids. The acetylenic hydrogen shifts to the adjacent carbon and one atom of molecular oxygen is incorporated into the carboxylic acid group in these transformations, which are subject to a large kinetic isotope effect when the acetylenic hydrogen is replaced by deuterium. The same products an...

The use of acetylenic acid analogs differing in chain length or position of the triple bonds permitted the systemic study of structure activity relationships for the arachidonate metabolizing enzymes (i.e, cyclo-oxygenase and lipoxygenase) in platelets and the relationship of these enzymes to aggregation. We were able to demonstrate analogs that were differentially selective in altering platele...

A new acetylenic alkaloid was isolated from the sponge Leucetta sp. The structure was established by analyzing spectroscopic data. The alkaloid showed cytotoxicity IC₅₀ 2.5 μg/mL against NBT-T2 cells.

A new polyunsaturated brominated fatty acid possessing acetylenic bonds 1 was isolated from the Indonesian sponge Haliclona sp. The structure of compound 1 was elucidated by analyzing its spectral data. It showed moderate cytotoxicity against cultured cells.

A novel, convenient and efficient multi-component reaction for synthesis of phosphonate derivatives from activated acetylenic compounds with 2-hydroxyacetophenone in the presence of phosphites in water lead to the formation of phosphonates in good yields.