Alzheimer’s disease (AD) is the most common type of dementia, more than 100 years ago the alzheimer’s disease was first identified, but research into its risk factors, causes, symptoms, and treatment has gained momentum only in the last 30 years. The cholinesterase inhibitors (ChEIs) were the first anti-Alzheimer drugs approved by the Food and Drug Administration (FDA), by inhibiting acetylchol...

Early research into Alzheimer's disease launched the cholinergic hypothesis, based on the correlation between central cholinergic deficiency and clinical measures of cognitive decline. This was epitomized in therapeutic strategies employing a variety of procholinergic agents, of which only the inhibitors of cholinesterase (ChE), the enzyme thai hydrolyzes acetylcholine in the synaptic cleft, ha...

BACKGROUND In this study, benzothiazole-piperazine compounds were synthesized by condensing the functional groups of donepezil (DNP), FK-960, and sabeluzole, which are known to have therapeutic potential against Alzheimer's disease, with the aim of obtaining new and potent anti-Alzheimer agents. METHODS Initially, acetylcholinesterase/butyrylcholinesterase enzyme inhibition activities of the ...

Alzheimer's disease (AD) is the most common type of senile dementia, characterized by cognitive deficits related to degeneration of cholinergic neurons. The first anti-Alzheimer drugs approved by the Food and Drug Administration were the cholinesterase inhibitors (ChEIs), which are capable of improving cholinergic neurotransmission by inhibiting acetylcholinesterase. The most common ChEIs used ...

BACKGROUND Patients with dementia of the Alzheimer type (DAT) respond variably to treatment with acetylcholinesterase inhibitors. OBJECTIVE To determine whether measures of hippocampal volume and shape predict the response to donepezil in patients with DAT. DESIGN T1-weighted, magnetic resonance images were obtained from patients with DAT, who subsequently underwent treatment with donepezil...

Alzheimer is an age-dependent disease mostly with genetic origin. In this disorder, acetylcholine is decreased which results in deterioration of short-term memory. Many researches have been focused on finding new sources of medications with more potency and less side effects and investigating acetylcholinesterase inhibitors (AChEIs) has been the center of many researches. In the present study, ...

The compositions of essential oils (EOs) from Spanish marjoram (Thymus mastichina L.) grown in several bioclimatic zones of Murcia (SE Spain) were studied to determine their absolute and relative concentrations using gas chromatography-mass spectrometry. 1,8-Cineole and linalool were the main components, followed by α-pinene, β-pinene and α-terpineol. (-)-Linalool, (+)-α-terpineol and (+)-α-pin...

In this study, Daphne laureola L., a European–Mediterranean species, was investigated for its antioxidant properties using different in vitro bioassays, namely 2,2?-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), 2,2-diphenyl-1-picrylhydrazyl (DPPH), Ferric Reducing Activity Power (FRAP), and ?-carotene bleaching assays. The acetylcholinesterase (AChE) butyrylcholinesterase (BChE) inh...