A 13-year-old epileptic girl took an overdose of acetaminophen (Tylenol) and phenobarbital. Hepatic encephalopathy developed and the patient died eight days later. Necropsy revealed extensive centrilobular necrosis of the liver, degeneration of the renal distal tubules, and infarcted and demyelinated foci throughout the white matter of the cerebral cortex. Electron microscopy of intact hepatocy...

Giacoppe GN, Degler DA Rapidly evolving adult respiratory distress syndrome with eosinophilia of unknown causse in previously healthy active duty soldiers at an Army training center: report of hvo cases hfil hfed. determined rapidly given the amount of time and effort needed to secure a suitable matched donor In those selected for transplant, 40 to 50% will die while awaiting a suitable donor '...

Drug-induced human hepatotoxicity is difficult to predict using the current in vitro systems. In this study, long-term 3D organotypic cultures of the human hepatoma HepaRG cell line were prepared using a high-throughput hanging drop method. The organotypic cultures were maintained for 3 weeks and assessed for (1) liver specific functions, including phase I enzyme and transporter activities, (2)...

Acetaminophen-induced hepatotoxicity has been attributed to covalent binding of the reactive metabolite N-acetyl-p-benzoquinone imine to cysteine groups on proteins as an acetaminophen-cysteine conjugate. We report a high-performance liquid chromatography with electrochemical detection (HPLC-ECD) assay for the conjugate with increased sensitivity compared with previous methods. Previous methods...

Hydrocodone is a semisynthetic opioid, which has been used for decades as a short-acting analgesic combined with acetaminophen (or less commonly ibuprofen). Several long-acting, non-acetaminophen-containing hydrocodone formulations are undergoing trials in the US under the auspices of the US Food and Drug Administration, and may be available shortly. This article reviews some of the advantages ...

Purpose: Acetaminophen is safe drug but it may cause hepatic failure in high doses. N-acetyl cysteine (NAC) used treatment of acetaminophen intoxication. Resveratrol be experimental intoxication models. Purpose, compare the efficacy NAC and resveratrol treatments intoxication.
 Materials Methods: We 34 rabbits. 6 rabbits were included control group 7 enrolled other groups APAP group, anima...

Chronic excess ingestion of nonsteroid anti-inflammatory drugs causes renal medullary necrosis. Previously, using an immortalized line of mouse inner medullary collecting ducts cells (mIMCD3), we found that acetaminophen, salicylic acid, and caffeine are toxic, and the effects of acetaminophen and caffeine are strongly additive. Furthermore, toxicity was greater in proliferating than in nonprol...

Unexpected drug toxicity is a critical problem for the pharmaceutical industry. Toxicity problems cause around 40% of drug candidates to be discontinued, oftentimes only after significant resources have been invested. Furthermore, drug-induced liver injury (DILI) is the most common reason already approved drugs are withdrawn from the marker, and causes half of all cases of acute liver failure, ...