abiraterone acetate

Won Kim Li Zhang John H Wilton Gerald Fetterly James L Mohler Vivian Weinberg Allison Morse Russell Z Szmulewitz Terence W Friedlander Lawrence Fong Amy M Lin Andrea L Harzstark Arturo Molina Eric J Small Charles J Ryan

PURPOSE Patients previously treated with ketoconazole were excluded from phase III trials of abiraterone acetate due to potential overlapping mechanism of action. The purpose of this study was to determine the clinical utility of abiraterone and its impact on circulating androgens following ketoconazole. EXPERIMENTAL DESIGN Chemotherapy-naïve patients with progressive metastatic castration-re...

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LATITUDE: A Phase III, Double-Blind, Randomized Trial of Androgen Deprivation Therapy with Abiraterone Acetate Plus Predni- sone or Placebos in Newly Diagnosed High-Risk Metastatic Hormone-Naive Prostate Cancer

2017

Keyan Salari

Dr. Fizazi and colleagues presented their much anticipated results from the LATITUDE trial at the 2017 American Society of Clinical Oncology (ASCO) annual meeting. LATITUDE is a phase III, double-blind, randomized study that tested androgen deprivation therapy (ADT) with abiraterone acetate (AA) plus prednisone (P) vs. ADT + placebo in men newly diagnosed with highrisk metastatic hormone-naïve ...

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Very Fast Recovery of Acute Disseminated Intravascular Coagulation with Abiraterone Acetate in a Patient with Bone Metastases from Castrate-Resistant Prostate Cancer

2014

Hélène Gauthier Camille Serrate Damien Pouessel Christine leMaignan Luis Teixeira Stéphane Culine

Disseminated intravascular coagulation (DIC) is a rare, potentially life-threatening complication of advanced prostate carcinoma. We report the successful treatment with abiraterone acetate of acute DIC related to a progressive bone metastatic disease in a chemotherapy-naïve patient with castrate-resistant prostate cancer.

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Efficacy and safety of second-line agents for treatment of metastatic castration-resistant prostate cancer progressing after docetaxel. A systematic review and meta-analysis.

Journal: :Archivio italiano di urologia, andrologia : organo ufficiale [di] Societa italiana di ecografia urologica e nefrologica 2015

Gianpaolo Perletti Elena Monti Emanuela Marras Anne Cleves Vittorio Magri Alberto Trinchieri Paul S Rennie

OBJECTIVE We performed a systematic review of the literature to assess the efficacy and the safety of second-line agents targeting metastatic castration-resistant prostate cancer (mCRPC) that has progressed after docetaxel. Pooled-analysis was also performed, to assess the effectiveness of agents targeting the androgen axis via identical mechanisms of action (abiraterone acetate, orteronel). ...

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Circulating tumor cell biomarker panel as an individual-level surrogate for survival in metastatic castration-resistant prostate cancer.

Journal: :Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2015

Howard I Scher Glenn Heller Arturo Molina Gerhardt Attard Daniel C Danila Xiaoyu Jia Weimin Peng Shahneen K Sandhu David Olmos Ruth Riisnaes Robert McCormack Tomasz Burzykowski Thian Kheoh Martin Fleisher Marc Buyse Johann S de Bono

PURPOSE Trials in castration-resistant prostate cancer (CRPC) need new clinical end points that are valid surrogates for survival. We evaluated circulating tumor cell (CTC) enumeration as a surrogate outcome measure. PATIENTS AND METHODS Examining CTCs alone and in combination with other biomarkers as a surrogate for overall survival was a secondary objective of COU-AA-301, a multinational, r...

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