background: clomiphene citrate (cc) is the first line agent used for ovulation induction in patients with polycystic ovarian syndrome (pcos). however, there is marked discrepancy between the ovulation and pregnancy rates achieved, which may be attributed to the undesirable effect of cc on cervical mucus and endometrium. objective: the aim of this study was to evaluate the effect of isosorbid mo...

Background: Ovulatory dysfunction is a common cause of infertility and polycystic ovary syndrome (PCOS) the main reason this dysfunction. PCOS most endocrinopathy in women childbearing age. A combination ovarian stimulation or superovulation with intrauterine insemination (IUI) remains an important option available to specialist widely used treatment modality for broad range indications. Object...

OBJECTIVE To explore the effects of letrozole (LE) in combination with low-dose intramuscular injection of human menopausal gonadotropin (HMG) on the ovulation induction and pregnancy of patients with polycystic ovary syndrome (PCOS). METHODS A total of 156 patients with PCOS infertility were randomly divided into an LE group, a clomiphene citrate (CC) group and an LE + HMG group (n= 52). LE ...

Polycystic ovary syndrome (PCOS), one of the most frequent endocrine diseases, affects approximately 5%-10% of women of childbearing age and constitutes the most common cause of female sterility regardless of the need or not for treatment, a change in lifestyle is essential for the treatment to work and ovulation to be restored. Obesity is the principal reason for modifying lifestyle since its ...

The coexistence of intrauterine and ectopic pregnancy (heterotopic pregnancy) occurs in 1/30,000 of spontaneous pregnancies, 1/900 in Clomiphene citrate induced pregnancies and rises to 1% in assisted reproduction. It is a life-threatening condition with diagnostic and therapeutic complexities. There is strong association between infertility and ectopic pregnancy. Risk factors for ectopic pregn...

Objective: N-acetyl-cysteine (NAC) has been shown to enhance the action of clomiphene citrate in ovulation induction. The objective of this study was to examine the use of NAC with clomiphene citrate for ovarian stimulation in assisted conception as a model for "Friendly IVF" Design: pilot study Materials and methods: Twenty infertile patients undergoing IVF/ICSI cycles were offered NAC, 1,200 ...

Anovulatory disorders are a primary cause of female infertility. Polycystic ovarian syndrome is the major cause of anovulation and is generally associated with obesity. Lifestyle changes to encourage weight loss are the initial therapy for overweight and obese patients, followed by clomiphene citrate for ovulation induction. For those patients who fail to ovulate on clomiphene citrate, alternat...

Most women with obesity are fertile, although increases the risk of infertility. This review describes influence on reproductive health before and during pregnancy postpartum. It also discusses multidisciplinary management a woman’s period based scientific literature subject published from January 2015 to March 2022. Obesity is factor for endometrial hyperplasia cancer. Women have lower respons...

Background: Clomiphene citrate (CC) is still holding its place as the first-line treatment for induction of ovulation in polycystic ovary syndrome (PCOS) patients.  Objective: to assess effect extended clomiphene on pregnancy outcomes resistant PCOS. Patients and methods: this study was conducted 48 PCO patients with CC resistance attended Obstetrics Gynecology Outpatient Clinic at Menoufia U...

Heterotopic pregnancy, defined as simultaneous intra- and extrauterine gestation is diagnostically challenging. The incidence rate of heterotopic pregnancy 27-fold higher after assisted reproductive technology than spontaneous conception; nevertheless, it relatively rare (reported 0.003％). We report a case laparoscopically diagnosed pregnancy. A 37-year-old primipara, who conceived intrauterine...