نتایج جستجو برای: a172
تعداد نتایج: 256 فیلتر نتایج به سال:
Abstract Glioblastoma (GBM) is a WHO grade IV glioma whose heterogeneous nature and stem-like features contribute to resistance conventional chemotherapeutics. Previously, antiretrovirals have been proposed as anti-neoplastic agents, but their clinical efficacy limited. With the advent of modern anti-retroviral combinatorial therapy, we sought repurpose FDA-approved drugs for glioblastoma. Here...
One of the modern methods treating patients with primary and recurrent brain tumors is radiosurgical irradiation using Gamma Knife, which allows therapeutic doses to be delivered not exceeding 2.5 cm in diameter 1–2 sessions. Tumor cells on periphery this tissue volume that receive lower radiation can resume proliferation serve as a source recurrence. The increase dose may cause necroses format...
dates fruit has been used as staple food in the middle east for thousands of years and various types of dates are found worldwide. dates and their constituents show various roles in diseases prevention and treatment through anti-oxidant, anti-inflammatory, anti-bacterial activity. in the present study we investigated the activity of aqueous and n-hexane extracts of phoenix dactylifera l. fruit ...
Reduction in the mRNA and protein expression of lipocalin-like prostaglandin D(2) (PGD(2)) synthase (PGDS), the main arachidonic acid metabolite produced in neurons and glial cells of the central nervous system, is a significant biological event involved in the malignant progression of astrocytomas and is predictive of poor survival. In vitro, the addition of the main PGDS metabolite, PGD(2), t...
Sodium butyrate (SB), a short chain (C-4) saturated fatty acid, is present in the human bowel at increased concentrations (~2 mM) as a food metabolite. It has been demonstrated that SB exerts an anti-tumor effect as a histone deacetylase inhibitor; however, its precise mechanism of action remains to be elucidated. The present study focused on the mechanisms underlying the effects of SB on gliob...
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