نتایج جستجو برای: a crocin

تعداد نتایج: 13432037  

2017
Azadehalsadat Hosseini Dastgerdi Maryam Radahmadi Ali Asghar Pourshanazari Hajaralsadat Hosseini Dastgerdi

Background Chronic stress adversely influences brain functions while crocin, as an effective component of saffron, exhibits positive effects on memory processes. This study investigated the effects of different doses of crocin on the improvement of learning and memory as well as corticosterone (CORT) levels in the hippocampus and frontal cortex of rats subjected to chronic stress. Materials a...

Journal: :Phytotherapy research : PTR 2012
Hossein Hosseinzadeh Hamid Reza Sadeghnia Fatemeh Abbasi Ghaeni Vahideh Sadat Motamedshariaty Seyed Ahmad Mohajeri

Cerebral ischemia produces brain damage and related behavioral deficits such as memory. In this study, a rat model of chronic cerebral hypoperfusion was used to determine whether saffron extract and crocin, which are potent antioxidants and free radical scavengers, can reduce vascular cognitive impairment. Male adult Wistar rats were administered different doses of an aqueous solution of crocin...

Journal: :DNA and cell biology 2008
Hossein Hosseinzadeh Akram Abootorabi Hamid R Sadeghnia

This study was designed to examine the effect of aqueous extract of Crocus sativus stigmas (CSE) and crocin (trans-crocin 4) on methyl methanesulfonate (MMS)-induced DNA damage in multiple mice organs using the comet assay. Adult male NMRI mice in different groups were treated with either physiological saline (10 mL/Kg, intraperitoneal [ip]), CSE (80 mg/Kg, ip), crocin (400 mg/Kg, ip), MMS (120...

2014
Mahin Dianat Mahdi Esmaeilizadeh Mohammad Badavi Ali Reza Samarbaf-zadeh Bahareh Naghizadeh

BACKGROUND Myocardial Injury caused by ischemia-reperfusion leads to cardiac dysfunction, tissue injury and metabolic changes. The production of reactive oxygen species (ROS) and lipid peroxidation are accompanied by ischemia-reperfusion injury. OBJECTIVES The aim of this study was to assess the cardio protective potential effects of crocin in comparison with vitamin E on antioxidant capacity...

2016
Amir Abbas Farshid Esmaeal Tamaddonfard Masoumeh Moradi-Arzeloo Navideh Mirzakhani

OBJECTIVE Crocin is a saffron constituent with a potent anti-oxidant activity. The present study investigated the effects of crocin and insulin treatments (alone or in combination) on cardiac function and pathology in diabetic rats. MATERIALS AND METHODS Diabetes was induced by intraperitoneal (i.p.) injection of streptozotocin (STZ, 50 mg/kg). Thereafter, crocin (5, 10 and 20 mg/kg, i.p.), s...

Journal: :Iranian biomedical journal 2010
Mohsen Khalili Faezeh Hamzeh

BACKGROUND The involvement of water-soluble carotenoids, crocins, as the main and active components of Crocus sativus L. extract in learning and memory processes has been proposed. In the present study, the effect of crocins on sporadic Alzheimer's disease induced by intracerebroventricular (icv) streptozocin (STZ) in male rats was investigated. METHODS Male adult Wistar rats (n = 90 and 260-...

2017
Mohammad Naser Shafei Abdolali Faramarzi Abolfazl Khajavi Rad Akbar Anaeigoudari

OBJECTIVE Angiotensin II (Ang II), the main product of renin-angiotensin system (RAS) has a well-known role in cardiovascular regulation. Over-production of Ang II is one of the important underlying mechanisms of hypertension. In this study, the effect of crocin on cardiovascular responses in rats with acute hypertension induced by Ang II was evaluated. MATERIALS AND METHODS Rats were divided...

2017
Mücella Arikan Yorgun Khalid Rashid Alexander Aslanidis Charlotte Bresgen Katharina Dannhausen Thomas Langmann

Microglia activation plays an important role in immune responses in the CNS including the retina. Crocin, a plant-derived carotenoid, has been reported to possess anti-inflammatory, anti-apoptotic and anti-oxidative capacity in models of retinal damage and degeneration. If these neuroprotective effects could be mediated by direct modulation of microglial cells is unclear. Here, we examined the ...

Journal: :iranian journal of basic medical sciences 0
esmaeal tamaddonfard department of basic sciences, faculty of veterinary medicine, urmia university, urmia, iran amir abbas farshid department of pathobiology, faculty of veterinary medicine, urmia university, urmia, iran elham ahmadian faculty of veterinary medicine, urmia university, urmia, iran abbas hamidhoseyni faculty of veterinary medicine, urmia university, urmia, iran

objective(s): crocin is a constituent of saffron and has many biological functions. the present study aimed to investigate the effects of intraperitoneal (ip) injection of crocin on sciatic nerve regeneration in male wistar rats. materials and methods: fifty-four rats were divided into 9 groups: groups 1-4 (intact + normal saline and intact + crocin at doses of 5, 20 and 80 mg/kg, respectively)...

2013
Lan Gao Bi-Yun Zhu

Gardenia fruit (fruit of Gardenia jasminoides Ellis) is used as a natural pigment resource and a Chinese traditional medicine. The white mesocarp turning orange or red that occurs during gardenia fruit maturation arises from the production and accumulation of the apocarotenoids, especially crocin-1, which is derived from carotenoid. Meanwhile, the major medical component geniposide is accumulat...

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