99mTc-Labeled annexin V has been used for the imaging of tumor apoptosis induced by chemotherapy. However, owing to the short half-life of annexin V, multiple injections of the radiotracer are necessary to capture the peak apoptotic activity. In this study, we evaluated the imaging properties of an 111Inlabeled, long-circulating annexin V. Methods: Both polyethylene glycol (PEG) and the metal c...

Aim: The aim of this study was to assess the role of labelled leukocyte scintigraphy in the diagnosis and monitorization of response to therapy of patients with active bronchiectasis. Material and methods: Twenty patients underwent 99mTechnetium hexamethylpropyleneamine oxime (99mTc-HMPAO) labelledwhite blood cell (WBC) scintigraphy. A second scintigraphywas performed in 13 patients at 10 day o...

Various non-invasive investigations were carried out in patients infected with HIV who had respiratory symptoms with and without pneumocystis pneumonia (with pneumonia, n = 13 (five smokers); without pneumonia, n = 22 (13 smokers]. These included chest radiography; lung function tests (forced expiratory volume in one second, forced vital capacity; transfer factor and coefficient for carbon mono...

Background Familial amyloid polyneuropathy (FAP) is a severe hereditary disease, due to production by the liver of a genetic variant transthyretin (TTR) resulting in tissue amyloid deposits. Cardiac involvement is of major prognostic value. Diphosphonate scintigraphy has been proposed as a diagnostic tool for TTR-related cardiac amyloidosis, but there is no consensus on the optimal radiopharmac...

BACKGROUND Skeletal uptake of 99mTc labelled methylene diphosphonate (99mTc-MDP) is used for producing images of pathological bone uptake due to its incorporation to the sites of active bone turnover. This study was done to validate bone turnover markers using total skeletal uptake (TSU) of 99mTc-MDP. METHODS 22 postmenopausal women (52-80 years) volunteered to participate. Scintigraphy was p...

The purpose of this study was to establish whether liposomes administered via the intravenous route promote granulocyte aggregation and pulmonary leukostasis. White cells (labelled with [111In]tropolanate) and positively and negatively charged liposomes (containing entrapped [99mTc]DTPA) were administered i.v. to rats. The blood clearance and tissue distribution of 111In label was not altered b...

BACKGROUND The permeability of the alveolar-capillary barrier to technetium-99m labelled diethylenetriamine pentaacetate (99mTc DTPA) is known to be greatly increased in smokers, but the underlying mechanism is poorly understood. Abnormal permeability of the alveolar epithelium as well as impaired surfactant function has been suggested. The purpose of this study was to examine transudation of u...