217 words. Introduction: 790 words. Discussion: 1,240 words. Abreviations : AHR: Aryl hydrocarbon receptor; AhRE: Ah receptor response element (also named XRE, for xenobiotic, and DRE, for dioxin response element); AR: Androgen receptor; ARE: Androgen receptor response element; ARNT: Aryl hydrocarbon receptor nuclear translocator; bHLH: basic region-helix-loop-helix; CDT: Charcoal-dextran treat...

BACKGROUND Three new analogs of berberine with aryl/ arylalkyl amino carbonyl methyl substituent at the 9-position of the isoquinoline chromophore along with berberrubine were studied for their binding to tRNA(phe) by wide variety of biophysical techniques like spectrophotometry, spectrofluorimetry, circular dichroism, thermal melting, viscosity and isothermal titration calorimetry. METHODOLO...

6-carbethoxy-5-(3'-bromophenyl)-3-aryl-2-cyclohexenones 2a-j were obtained from the1-aryl-3-(3'-bromophenyl)-2-propene-1-ones 1a-j by micheal addition of ethyl acetoacetate, followed by internal claisen condensation. reaction of 2a-j with hydrazine hydrate afforded the corresponding 6-aryl-4-(3'-bromophenyl)-3-oxo-2,3a,4,5-tetrahydro-2h-indazoles 3a-j. the structures of newly syn...

A Pd-catalyzed domino reaction of 1,8,13-tribromo-9-methoxytriptycenes is reported. Under conventional Suzuki coupling conditions, the triptycenes underwent multiple transformations to give 1,9-bridged triptycenes. Based on mechanistic investigations, a single Pd catalyst functions as Pd0, PdII and PdIV species catalyze four distinct processes: 1) aryl-to-alkyl 1,5-Pd migration, 2) intramolecul...

3- And 9-component Pd(0) catalysed assembly of allenes, aryl iodides and N-nucleophiles with concomitant installation of trisubstituted Z-alkenes is readily achieved.

A net trans C-N reductive elimination reaction is observed from a macrocyclic aryl-Cu(III) complex, and a mechanistic study of this reaction indicates that coordinating ligands play a role in mediating this unusual transformation.

The C-C coupling of N,N'-bis(5-norbornene-2,3-dicarboximide) (3) and N,N'-bis(7-oxa-5-norbornene-2,3-dicarboximide) (6) with aryl and heteroaryl iodides gave under reductive Heck conditions the C-aryl(hetaryl), substituted N,N'-bistricyclic imides 7a-f and 8a,b. The fused spiro-1,3-indandionolylpyrrolidine compounds, 9, 10 and 11 were also obtained from ninhydrine, sarcosine and 3 or 6 via [3+2...

A SO3 H-containing solid acid namely SO3 H-functionalized phthalimide (SFP) was synthesized from phthalimide and chlorosulfonic acid, and identified by studying its FT-IR, 1 H and 13C NMR, Mass, XRD, TG and DTG spectra. Afterward, its catalytic activity was examined for the solvent-free condensation of dimedone (5,5-dimethyl-1,3-cyclohexanedione) (2 eq.) with arylaldehydes (1 eq.). The results ...