The aim. Synthesis of 1-benzylsubstituted derivatives N-[(2,4-dichlorophenyl)methyl]-2-(2,4-dioxo-1h-quinazolin-3-yl)acetamide, and determination affinity to GABAergic biotargets with the following anticonvulsant activity estimation using PTZ-induced seizures model in mice.
 Materials methods. Standard organic synthesis methods were used; structure synthesized compounds was proved by eleme...

MG 50-3-1 (3, trisodium 1-amino-4-{4-[4-chloro-6-(2-sulfophenylamino)-1,3,5-triazin-2-ylamino]-2-sulfophenylamino}-9,10-dioxo-9,10-dihydroanthracene 2-sulfonate) is the most potent and selective antagonist (IC₅₀ 4.6 nM) for "P2Y₁-like" nucleotide-activated membrane receptors in guinea-pig taenia coli responsible for smooth muscle relaxation. Full characterization of the compound, however, e.g.,...

Two novel lanostane-type triterpenes, Ganolactone B and Ganoderiol A triacetate, were isolated from the fruiting bodies of G. sinense, together with six known compounds. The structures of the two new triterpenes were determined as 3beta,7beta- dihydroxy-11,15-dioxo-lanosta-8-en-24-->20 lactone (1) and 3beta,24,26-triacetoxy-5alpha-lanosta-7,9(11)-dien-25-ol (2), respectively, by chemical and sp...

In the title mol-ecular salt [systematic name: 2-methyl-pyridinium 5-(2,4-dinitro-phen-yl)-1,3-dimethyl-2,6-dioxo-1,2,3,6-tetra-hydro-pyrimidin-4-olate], C(6)H(8)N(+)·C(12)H(9)N(4)O(7) (-), the cation and anion are linked a through strong N-H⋯O hydrogen bond. In the crystal, C-H⋯O inter-actions link the ions, generating a chain along [010].

1, 8-Dioxo-octahydroxanthene derivatives have efficiently been synthesized from dimedone and aromatic aldehydes using [Fe(III)(salen)Cl] complex as an efficient and homogeneous catalyst in molten tetrabutyl ammonium bromide. This methodology offers several advantages, such as good yields, short reaction times, simple procedure, and mild conditions.

Some novel 2,3-dioxo-5-(substituted)-arylpyrroles have been synthesized. Among these, pyrrolidine compound 1b was converted to 2,3-dioxo-5-aryl pyrrolidine 2b. Finally a set of hydrazone derivatives was obtained from the reaction of 2b with various hydrazine salts. The structures of all the new synthesized compounds were confirmed by elemental analyses, IR and 1H-NMR spectra.

2-Amino-1,3-dimethylimidazolium 2,2-dimethyl-4,6-dioxo-1,3-dioxanide (6) has been obtained from the reaction of 2,2-dimethyl-4,6-dioxo-1,3dioxan (1, “Meldrum’s acid”) and 2-imino-1,3-dimethylimidazoline (5) in excellent yield. The unit cell of 6 contains two crystallographically independent anions lying on crystallographic mirror planes. The structure of the anion is compared with that of compo...

In order to determine the regularities of the structure-analgesic activity relationship, the peculiarities of obtaining, the spatial structure, and biological properties of 4-methyl-2,2-dioxo-1H-2λ⁶,1-benzothiazine-3-carboxylic acid and some of its derivatives have been studied. Using nuclear magnetic resonance (NMR) spectroscopy and X-ray diffraction analysis, it has been proven that varying t...