A series of N-[(4-arylpiperazin-1-yl)-alkyl]-2-azaspiro[4.5]decane-1,3-dione derivatives were synthesized and evaluated for their anticonvulsant and neurotoxic properties. The main modifications to that series of compounds consisted in the introduction of an aromatic area to the cyclohexane ring as a flexible fragment with conformational freedom (1a-h), or as a rigidified skeleton (2a-h). Excep...

Phytochemical profiling was undertaken on the crude extracts of Drosera magna to determine nature chemical constituents present. In total, three new flavonol diglycosides (1–3), one flavan-3-ol glycoside (4), and 12 previously reported compounds (5, 9), (15), flavanone (8), 1,4-napthoquinone (6, 7, 13, 14), 2,3-dehydroxynapthalene-1,4-dione (10–12), phenolic acid (16) structure classes were iso...

The photogeneration of 2,3,9,10-tetrabromopentacene from its precursor dione by photodecarbonylation was investigated. An unusual photodimer, 3,3',9,9',10,10'-hexabromo-2,2'-bipentacene, is produced.

We have used equations for partition coefficients of compounds from water and the gas phase to various solvents to obtain descriptors for pentane-2,4-dione and 21 of its derivatives. These descriptors can then be used to estimate further partition coefficients into a wide variety of solvents. The descriptors also yield information about the properties of pentane-2,4-dione and its derivatives. P...

Curcumol is one of the major components of the essential oil of Curcuma wenyujin with the structure of a guaiane-type sesquiterpenoid hemiketal. It exhibits clear antitumor, antihepatic fibrosis, antioxidant, and antimicrobial activities. In this article, the metabolism of curcumol in rats was investigated by characterizing metabolites excreted into urine. Sixteen phase 1 metabolites of curcumo...

The asymmetric unit of the title compound, C(8)H(6)N(2)O(2)·C(8)H(5)NO(6)·H(2)O, contains mol-ecules of 1,4-dihydro-quinoxaline-2,3-dione, 5-nitro-isophthalic acid and a solvent water. In the crystal structure, mol-ecules are linked into a three-dimensional network by inter-molecular N-H⋯O and O-H⋯O hydrogen bonds.

The asymmetric unit of the title compound, C(10)H(6)N(2)O(2), contains two independent mol-ecules. The dihedral angles between the acetonitrile and the 1H-isoindole-1,3(2H)-dione units are 69.0 (7)° and 77.0 (5)° in the two mol-ecules. One of the two terminal N atoms is disordered over two positions in a 0.66 (8):0,34 (8) ratio. In the crystal structure, the mol-ecules are linked by inter-molec...

The cyclization of b-anilino propionic acids in the presence of polyphosphoric acid (PPA) afforded the 2,3-Dihydroquinoline-4-(1H)-ones in good yields. N,N'-bis(2-carboxyethyl)-4-methyl-1,2-diaminobenzene (7) is cyclized under this condition to produce the 1,5-diaza-2,3,6,7-tetrahydro-4-methyl-pheranthrene-4,8-dione(bis-quinolone) (8).

Obesity and metabolic syndrome, along with drug dependence (nicotine, alcohol, opiates), are two of the major therapeutic applications for CB(1) cannabinoid receptor antagonists and inverse agonists. In the present study, we report the synthesis and structure-affinity relationships of 1,5-diphenylimidazolidine-2,4-dione and 1,3,5-triphenylimidazolidine-2,4-dione derivatives. These new 1,3,5-tri...