INTRODUCTION 272 CLINICAL ASPECTS OF OBESITY AND CARDIOMETABOLIC DISEASE 273 Background – Do We Need Drugs for Obesity? 273 Current Drugs for Obesity and Their Limitations 274 Other Drugs – Withdrawn or No Longer Recommended for Routine Clinical Use 275 The Need for New Drugs 275 BIOLOGY AND GENETICS OF ENERGY REGULATION AND IMPLICATIONS FOR OBESITY 276 Short-Term (Episodic) Signals 276 Meal On...

INTRODUCTION Saccharomyces boulardii is a well-known probiotic worldwide, and there are numerous studies including experimental and clinical trials in children and adults by the use of S. boulardii. AREAS COVERED The objective of the present report is to provide an update on the evidence for the efficacy of S. boulardii CNCM I-745 in different clinical conditions. Saccharomyces boulardii is o...

belonging to the family Guttiferae. Some species of Cratoxylum have been used as traditional medicine. Previous chemical investigations of this genus have revealed the presence of xanthones, triterpenoids and flavonoids. In the course of our ongoing search for bioactive compounds from natural sources, hexane extract of the roots of C. cochinchinense exhibited cytotoxic activity against the NCI-...

Explanation ..................................................................................................... 227 Evaluation for acceptable daily intake ............................................................ 228 1. Biochemical aspects .......................................................................... 228 1.1 Absorption, distribution and excretion .................................

Connexin43 (CX43), a protein that forms gap junction channels and hemichannels in astrocytes, is downregulated in high-grade gliomas. Its relevance for glioma therapy has been thoroughly explored; however, its positive effects on proliferation are counterbalanced by its effects on migration and invasion. Here, we show that a cell-penetrating peptide based on CX43 (TAT-Cx43266-283) inhibited c-S...

We have examined the role of cell surface glycosaminoglycans in cell division: adhesion and proliferation of Chinese hamster ovary (CHO) cells. We used both wild-type (CHO-K1) cells and a mutant (CHO-745) which is deficient in the synthesis of proteoglycans due to lack of activity of xylosyl transferase. Using different amounts of wild-type and mutant cells, little adhesion was observed in the ...

Salmonella phage P22, which serves as an assembly paradigm for icosahedral double-stranded DNA viruses, packages its viral genome through a capsid channel (portal) comprising 12 copies of a 725-residue subunit. Secondary and tertiary structures of the portal subunit in monomeric and dodecameric states have been investigated by Raman spectroscopy using a His6-tagged recombinant protein that self...