of the 3H-label in their experiments is associated with the cells is difficult to interpret. Although some of the experiments by Hammes et al. are consistent with their “bound steroid” hypothesis (see, for example, Figure 2A), others are not (for example, see Figures 2B and 2C). At a concentration of 1 nM DHT plus 1 nM SHBG, 50% of the steroid exists in the free form. One nanomole of DHTSHBG an...

The recent proliferation of decentralized distributed hash table (DHT) proposals suggests a need for DHT benchmarks, both to compare existing implementations and to guide future innovation. We argue that a DHT-based query engine provides a unified framework for describing workloads and faultloads, injecting them into a DHT, and recording and analyzing the observed system behavior. To illustrate...

This paper investigates the development of a DHT-based storage engine for a database management system (DBMS). The storage engine is responsible for implementing the interface between an SQL query processor and a DHT, by translating operations based on relations to DHT standard operations. By combining DHTs to DBMSs we achieve scalability, decentralization, and fault tolerance, due to a DHT-bas...

Polycystic ovarian syndrome (PCOS) is the most common endocrine disorder in women of reproductive age, with a prevalence of 5-8%. Type 2 diabetes and cardiovascular disease (CVD) are its long-term complications. Targeted therapies addressing both these complications together are lacking. Glucagon like peptide-1 (GLP-1) agonists that are used to treat type 2 diabetes mellitus have beneficial eff...

As an append-only distributed database, blockchain is utilized in a vast variety of applications including the cryptocurrency and Internet-of-Things (IoT). The existing solutions show downsides communication storage scalability, as well decentralization. In this article, we propose LightChain, which first architecture that operates over Distributed Hash Table (DHT) participating peers. LightCha...

The androgen receptor (AR) mediates the growth of benign and malignant prostate in response to dihydrotestosterone (DHT). In patients undergoing androgen deprivation therapy for prostate cancer, AR drives prostate cancer growth despite low circulating levels of testicular androgen and normal levels of adrenal androgen. In this report, we demonstrate the extent of AR transactivation in the prese...

This article examines the role of the androgen dihydrotestosterone (DHT) in the healthy and diseased prostate and considers the implications of the data on DHT for therapeutic approaches to benign prostatic hyperplasia (BPH). Development and maintenance of the normal prostate, as well as development of BPH, depend on a functional androgen-signaling axis, components of which include: (1) testost...

Elevated serum chemerin levels correlate with increased severity of polycystic ovary syndrome (PCOS). However, the role of CMKLR1 signaling in ovarian biology under conditions of excess DHT remains unclear. In this study we compared the effects of continuous 90-day high dose DHT exposure (83.3 □g/day) on wild type and CMKLR1-deficient mice. DHT induced PCOS-like clinical signs in wild type mice...

To investigate the development of denervation supersensitivity to serotonin (5-hydroxytryptamine, 5-HT) in the amygdala (AMYG) and the ventral lateral geniculate nucleus (vLGN), single cell recordings, microiontophoretic, histochemical and biochemical techniques were used in the present study. 5-HT projections to the vLGN and the AMYG were destroyed by 5,7-dihydroxytryptamine (5,7-DHT, a relati...

OBJECTIVES It has been hypothesized that dihydrotestosterone (DHT), the main intracellular androgen in the prostate, affects prostatic tumour progression. In this study, we evaluated serum DHT levels at the time of prostate-cancer diagnosis in relation to survival. METHODS Sixty-five screening-detected patients diagnosed in 1988-1989 were followed for 15 yr. DHT levels at the time of diagnosi...