OBJECTIVE Caspase-8 (CASP8) plays a central role in the apoptotic pathway and aberrant regulation of this pathway may cause cancers. Previous studies investigating the association between CASP8 -652 6N ins/del polymorphism and colorectal cancer (CRC) risk showed inconclusive results. We performed a meta-analysis of all available studies to investigate this association. METHODS All studies pub...

The conversion of alpha-linolenate (18:3n-3) to docosahexaenoate (22:6n-3) in the presence of low and high dietary levels of linoleate (18:2n-6) is reported in young rats using [U-13C]-alpha-linolenic acid (18:2n-3*) and high precision gas chromatography-combustion isotope ratio mass spectrometry (GCC-IRMS). After consuming an 18:3n-3-deficient diet for 4 weeks, dams were bred and assigned to o...

Mycoplasma pneumoniae is a leading, worldwide cause of death and disability due to pneumonia. Mycoplasma pulmonis infection in mice is an invaluable model for the study of host defenses against respiratory mycoplasmas in vivo. C3H/HeN mice are much more susceptible to acute inflammatory lung disease due to M. pulmonis than C57BL/6N mice, but little is known about the chronic disease in these mo...

Abstract Autoimmune diseases play a critical role in the progression of infertility both sexes and their severity has been reported to increase with age. However, few reports have discussed effect on morphological features testis. Therefore, we compared alterations testes autoimmune model mice (MRL/MpJ-Fas lpr ) control strain (MRL/MpJ) those background (C57BL/6N) at 3 6 months. Furthermore, an...

This paper gives an integrable hierarchy of nonlinear evolution equations. In this hierarchy there are the following representative equations: ut = ∂ 5 xu − 2 3 , ut = ∂ 5 x (u 1 3 )xx − 2(u 1 6 )x u ; uxxt + 3uxxux + uxxxu = 0. The first two are in the positive order hierarchy while the 3rd one is in the negative order hierarchy. The whole hierarchy is shown integrable through solving a key 3×...

Observational studies on circulating fatty acid (FA) and primary prevention of hypertension have yielded inconsistent results, and the association among the Chinese population is not fully clear. The aim of the study was to discern important FAs that can discriminate hypertensive patients from normotensive persons, and investigate associations between the important FAs and risk of hypertension....

For some members of the Paramyxoviridae family of negative strand RNA viruses, efficient genome replication only occurs when the total genome length is a multiple of six (6N length, where N is any integer). To determine if this "rule of six" requirement applied to the replication of the prototype paramyxovirus simian virus 5 (SV5), defective interfering (DI) RNA genomes were generated by sequen...

Necessary conditions for the existence of (3; 6) generalized Whist tournament designs on v players are that v ≡ 0; 1 (mod 6). For v= 6n+ 1 it is shown that these designs exist for all n. For v = 6n, it is impossible to have a design for n = 1, but for n¿ 1 it is shown that designs exist, except possibly for 73 values of n the largest of which is n = 199. A solution is also provided for the only...

Using a plasmid transformation method and the RM search computer program, four type I restriction enzymes with new recognition sites and two isoschizomers (EcoBI and Eco377I) were identified in a collection of clinical Escherichia coli isolates. These new enzymes were designated Eco394I, Eco826I, Eco851I and Eco912I. Their recognition sequences were determined to be GAC(5N)RTAAY, GCA(6N)CTGA, G...