نتایج جستجو برای: 6c and flip03

تعداد نتایج: 16827281  

Journal: :AfCS-Nature Molecule Pages 2011

Journal: :Dalton transactions 2012
Zhou Dai Erik R Farquhar Dhruv P Arora Elizabeth M Boon

The H-NOX (Heme-Nitric oxide/OXygen binding) family of diatomic gas sensing hemoproteins has attracted great interest. Soluble guanylate cyclase (sGC), the well-characterized eukaryotic nitric oxide (NO) sensor is an H-NOX family member. When NO binds sGC at the ferrous histidine-ligated protoporphyrin-IX, the proximal histidine ligand dissociates, resulting in a 5-coordinate (5c) complex; form...

Journal: :Journal of immunology 2013
John J Osterholzer Michal A Olszewski Benjamin J Murdock Gwo-Hsiao Chen John R Erb-Downward Natalya Subbotina Keely Browning Yujing Lin Roger E Morey Jeremy K Dayrit Jeffrey C Horowitz Richard H Simon Thomas H Sisson

The alveolar epithelium is characteristically abnormal in fibrotic lung disease, and we recently established a direct link between injury to the type II alveolar epithelial cell (AEC) and the accumulation of interstitial collagen. The mechanisms by which damage to the epithelium induces lung scarring remain poorly understood. It is particularly controversial whether an insult to the type II AEC...

Journal: :Journal of immunology 2013
Hendrik W van Deventer Daniela A Palmieri Qing Ping Wu Everett C McCook Jonathan S Serody

Fibrocytes are circulating, hematopoietic cells that express CD45 and Col1a1. They contribute to wound healing and several fibrosing disorders by mechanisms that are poorly understood. In this report, we demonstrate that fibrocytes predispose the lung to B16-F10 metastasis by recruiting Ly-6C(+) monocytes. To do so, we isolated fibrocytes expressing CD45, CD11b, CD13, and Col1a1 from the lungs ...

Journal: :Hypertension 2007
Gregory Fink Melissa Li Yanny Lau John Osborn Stephanie Watts

Endothelin (ET) exerts powerful pressor actions primarily through activation of the ET(A) receptor subtype. The ET(B) receptor (ET(B)R) subtype, on the other hand, is generally thought to initiate physiological actions that decrease arterial pressure. Such actions include clearing ET from the bloodstream, initiating endothelium-mediated vasodilation, and facilitating renal sodium and water excr...

2005
J. Sereikaite

The interaction of the dye reactive bright red 6C with bovine serum albumin has been investigated. Formation of a complex between reactive bright red 6C and bovine serum albumin was detected by use of absorption difference spectroscopy. The curves obtained by titration of the protein against the dye were recorded at different pH and ionic strength of the solution. An unusual form of titration c...

2016
Tao Yu Alexander V. Soudackov Sharon Hammes-Schiffer

Soybean lipoxygenase (SLO) serves as a prototype for fundamental understanding of hydrogen tunneling in enzymes. Its reactivity depends on the active site structure around a mononuclear, nonheme iron center. The available crystal structures indicate five-coordinate iron, while magnetic circular dichroism experiments suggest significant populations of both five-coordinate (5C) and six-coordinate...

2007
Maria J. Cruz Matt J. Jarvis Steve Rawlings Katherine M. Blundell

We use the 6C** sample to investigate the co-moving space density of powerful, steepspectrum radio sources. This sample, consisting of 68 objects, has virtually complete K-band photometry and spectroscopic redshifts for 32 per cent of the sources. In order to find its complete redshift distribution, we develop a method of redshift estimation based on the K − z diagram of the 3CRR, 6CE, 6C* and ...

Journal: :Circulation 2009
Daqing Zhang Xiaohua Jiang Pu Fang Yan Yan Jian Song Sapna Gupta Andrew I Schafer William Durante Warren D Kruger Xiaofeng Yang Hong Wang

BACKGROUND Hyperhomocysteinemia (HHcy) is an independent risk factor for cardiovascular disease. Monocytes display inflammatory and resident subsets and commit to specific functions in atherogenesis. In this study, we examined the hypothesis that HHcy modulates monocyte heterogeneity and leads to atherosclerosis. METHODS AND RESULTS We established a novel atherosclerosis-susceptible mouse mod...

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