Some drugs have low bioavailability due to their poor aqueous solubility and/or slowdissolution rate in biological fluids. Stiripentol (STP) is a novel anticonvulsant drug that isstructurally unrelated to the currently available antiepileptics. It has poor aqueous solubilityand its solubility has to be enhanced accordingly. Polyethyleneglycol 6000 (PEG-6000) iscommonly utilized as a hydrophilic...

The EFAR project has measured peculiar motions in two distant volumes of the universe using Fundamental Plane (FP) distances for 85 clusters with 6000 km s −1 <cz<15000 km s −1. The scatter in distance about the FP is observed to be 20% per galaxy for EFAR sample, resulting in peculiar velocities with a median precision of 1075 km s −1 for the 50 clusters with 3 or more galaxies. We find that t...

In December 1998, a 488 node IBM RS/6000 SP sorted a terabyte of data (10 billion 100 byte records) in 17 minutes, 37 seconds. This is more than 2.5 times faster than the previous record for a problem of this magnitude. The SPsort program itself was custom-designed for this benchmark, but the cluster, its interconnection hardware, disk subsystem, operating system, file system, communication lib...

Near-infrared (NIR) spectra of carbonates have proved important in many disciplines including planetary exploration. Classically bands in the 4000-6000 cm(-1) (2.5-1.67 μm) region are assigned to [CO3(2-)] internal mode combinations and overtones. However band assignments remain equivocal. This study examines three prominent bands ((ca 4505 cm(-1) (2.219 μm), 4900 cm(-1) (2.041 μm) and 5145 cm(...

We describe a high-performance, compact optical frequency standard based on microfabricated Rb vapor cell and low-noise, external cavity diode laser operating the two-photon transition at 778 nm. The achieves an instability of 1.8x10$^{-13}$/$\sqrt{\tau}$ for times less than 100 s flicker noise floor 1x10$^{-14}$ out to 6000 s. At long integration times, is limited by variations in probe power ...

In 2009 all ECB publications feature a motif taken from the €200 banknote. Discussions with Máximo Hemingsen are also gratefully acknowledged. The views expressed in this paper are those of the author and do not necessarily reflect those of the European Central Bank. Fax +49 69 1344 6000 All rights reserved. Any reproduction, publication and reprint in the form of a different publication, wheth...

The performance of adaptive systems that consist of microscale on-chip elements [microelectromechanical mirror (mu-mirror) arrays and a VLSI stochastic gradient descent microelectronic control system] is analyzed. The mu-mirror arrays with 5 x 5 and 6 x 6 actuators were driven with a control system composed of two mixed-mode VLSI chips implementing model-free beam-quality metric optimization by...

In 2010 all ECB publications feature a motif taken from the €500 banknote. and an anonymous ECB WPS referee for helpful comments and suggestions. The opinions expressed herein are those of the authors and do not necessarily reflect those of the ECB or the Eurosystem. Fax +49 69 1344 6000 All rights reserved. Any reproduction, publication and reprint in the form of a different publication, wheth...