Liver fibrosis is the most common outcome of chronic liver diseases, and its progression to cirrhosis can only be effectively treated with liver transplantation. The amniotic membrane (AM) has been studied as an alternative therapy for fibrosis diseases mainly for its favorable properties, including anti-inflammatory, anti-scaring and immunomodulatory properties. It was recently demonstrated th...

Though the value of a right should be not lower than zero, negative voting premiums often appear in recent empirical evidence. The present paper highlights some possible measurement errors and contemporary proposes a new measure, the vote segment, which incorporates all dividend privileges. Results from Italian non-voting shares listed in the 1999-2008 period show that the more accurate measure...

BACKGROUND Hypoglycin A, found in seeds of Acer negundo, appears to cause seasonal pasture myopathy (SPM) in North America and is implicated in atypical myopathy (AM) in Europe. Acer negundo is uncommon in Europe. Thus, the potential source of hypoglycin A in Europe is unknown. HYPOTHESIS AND OBJECTIVES We hypothesized that seeds of Acer pseudoplatanus were the source of hypoglycin A in Europ...

[1]. Programa de Pós-Graduação em Medicina Tropical, Universidade do Estado do Amazonas, Manaus, AM, Brasil. [2]. Fundação de Medicina Tropical Dr. Heitor Vieira Dourado, Manaus, AM, Brasil. [3]. Laboratório de Genômica, Fundação Hospitalar de Hematologia e Hemoterapia do Amazonas, Manaus, AM, Brasil. [4]. Universidade Nilton Lins, Manaus, AM, Brasil. [5]. Programa de Pós-Graduação em Imunologi...

The accurate analytical measurement of binding affinities of polyclonal antibody in sera to heroin, 6-acetylmorphine (6-AM), and morphine has been a challenging task. A simple nonradioactive method that uses deuterium-labeled drug tracers and equilibrium dialysis (ED) combined with ultra performance liquid chromatography/tandem mass spectrometry (UPLC/MS/MS) to measure the apparent dissociation...

OBJECTIVE To compare the circadian intraocular pressure (IOP) reductions induced by latanoprost, brimonidine tartrate, and a fixed combination of timolol maleate and dorzolamide hydrochloride in patients with primary open-angle glaucoma (POAG) or ocular hypertension (OHT). METHODS In this crossover study, 10 patients with POAG and 10 with OHT were treated with latanoprost once a day, brimonid...

The alveolar macrophage (AM) population has been shown to be heterogeneous in composition as well as in function. The aim of our study was to assess morphological and functional features of AM in an experimental model of quartz-induced lung fibrosis by flow cytometric methods. Twelve cynomolgus monkeys were exposed 8 hr/day, 5 days/week for 26 months to either normal atmosphere (n = 5) or 5 mg/...