Novel disulfinyl derivatives based on 3,4-dichloro-2(5H)-furanone, aliphatic dithiols, and monoterpene alcohols were synthesized. Chiral bis-thioethers in the molecules of which dithiol fragment links two five-membered cycles at C4 atoms obtained reactions 5(S)-(l-menthyloxy)- 5(S)-(l-bornyloxy)-2(5H)-furanones with ethane-1,2-dithiol propane-1,3-dithiol acetone basic medium. The action an exce...

Interaction of biomaterials with blood components including neutrophils is responsible for some of the clinical complications that have occurred in cardiopulmonary bypass, hemodialysis, and ventricular assist procedures. The possibility of inhibiting the initial adhesion of neutrophils to biomaterials has been studied extensively, but the problem remains unsolved. In this study, we investigated...

This study characterized cardiac troponin T (cTnT) appearance and associated histological evidence of reversible or irreversible changes in myocardial ultrastructure, determined via electron microscopy, in rats undertaking isoproterenol (ISO) infusion or an endurance exercise challenge. Male rats were randomized into ISO and exercise groups. In ISO trials rats were killed 5 h (ISO-5H) and 24 h ...

5-Aryl-2(5H)-furanones can be synthesized by the Rh-catalyzed reactions of arylboronic acids with internal alkynes under a CO atmosphere.

A detailed climatology of ocean wind waves in the South Atlantic Ocean, based on ERA-5 reanalysis and a higher-resolution wave hindcast (ERA-5H), both developed by European Centre for Medium-Range Weather Forecasts, is presented. The higher resolution fields ERA-5H (22 km) allowed better description sea swell features compared to previous global regional studies along Brazilian coast. Overall, ...

To develop antiviral therapeutics against human coronavirus (HCoV) infections, suitable drug targets and corresponding lead molecules must be urgently identified. Here, we describe the discovery of a class HCoV inhibitors acting on nsp15, hexameric protein component viral replication-transcription complexes, endowed with immune evasion-associated endoribonuclease activity. Structure–activity re...

In the further research and synthesis of highly bioactive 3-methylrhodanine derivatives, preparation benzylidene rhodanines followed by bicyclization to form pyrazole compounds has been undertaken. Using a convenient simple method, twelve have synthesized including six rhodanine derivatives ranging from good excellent yield, with four phenylhydrazone two at low yield. The structures all were el...