Department of Zoology, University of Otago, PO Box 56, Dunedin 9054, New Zealand, Fluvial Ecosystem Research Section, Aquatic Ecosystem Protection Research Division, Water Science and Technology Directorate, Science and Technology Branch, Environment Canada, St. Lawrence Centre, 105 McGill Street, Montreal, QC H2Y 2E7, Canada, Division of Math, Science, and Technology, Farquhar College of Arts ...

We consider a risk model described by an ergodic stationary marked point process. The model is perturbed by a Lévy process with no downward jumps. The (modified) ladder height is defined as the first epoch where an event of the marked point process leads to a new maximum. Properties of the process until the first ladder height are studied and results of Dufresne and Gerber [Insurance: Math. Eco...

Specificity and sensitivity of a biological test describe the ability of the test to exclude false and to include true positives. A method is described for estimating such values for blood pressure measurement. Estimated values are given for various cut-off levels of the diastolic blood pressure. The method indicates that the optimal cut-off for defining hypertension is found to be at the blood...

The endocannabinoid system consists of cannabinoid CB1 and CB2 receptors, of endogenous agonists for these receptors known as ‘endocannabinoids’, and of processes responsible for endocannabinoid biosynthesis, cellular uptake and metabolism. There is strong evidence first, that this system up-regulates in certain disorders as indicated by an increased release of endocannabinoids onto their recep...

ion, 49 Adams, Cecil, 23 Adult Intelligence Scale, 44, 118 adult weight, 47, 48, 114 analysis, 49, 74, 88 anecdotal evidence, 2, 9 Anscombe’s quartet, 113 apparent effect, 8, 10, 20, 79 artifact, 8, 10 Australia, 37 average, 11, 68 bar plot, 15, 18 baseball, 61 basketball, 61 Bayes factor, 86 Bayes’s theorem, 63 Bayesian estimation, 77, 97, 104 Bayesian probability, 84, 86 Bayesianism, 54, 66, ...

there has been a highly significant increase in the number of patients with malignant mediastinal tumors in the last four decades. since these lesions are infrequently encountered and there are very few reports in iran concerning this issue, we performed this study to review our institutional experience of medias-tinal masses and to compare differences in the clinical spectrum between our study...

A high-throughput screening campaign was conducted to interrogate a 380,0001 small-molecule library for novel D2 dopamine receptor modulators using a calcium mobilization assay. Active agonist compounds from the primary screen were examined for orthogonal D2 dopamine receptor signaling activities including cAMPmodulation and b-arrestin recruitment. Although themajority of the subsequently confi...

A triangulation is said to be even if each vertex has even degree. It is known that every even triangulation on any orientable surface with sufficiently large representativity is 4-colorable [J. Hutchinson, B. Richter, P. Seymour, Colouring Eulerian triangulations, J. Combin. Theory, Ser. B 84 (2002) 225–239], but all graphs on any surface with large representativity are 5-colorable [C. Thomass...

Several studies have shown that renal failure decreases CYP3A activity and that uremic toxins may play a role via transcriptional or translational modifications of cytochrome P450 (P450) enzymes and direct inhibition of P450-mediated metabolism. In this study, we evaluated the relationship between CYP3A activity (using plasma concentration of 4b-hydroxycholesterol as a biomarker) and clinical c...

The mode of action of sulfanilyl fluoroquinolones (NSFQs) was investigated with NSFQ-104, NSFQ-105, and some structurally related compounds. Evidence arising from interactions with p-aminobenzoic acid and trimethoprim suggested that a sulfonamidelike mechanism of action makes little or no contribution to the in vitro activity of NSFQs. NSFQ-105 showed an activity that inhibits gyrase-catalyzed ...